Dually modified transmembrane proteoglycans in development and disease.
Dually modified transmembrane proteoglycans in development and disease.
复制标题
DOI：
10.1016/j.cytogfr.2017.12.003
复制
发表时间：
2018-03
影响因子：
13
通讯作者：
Mythreye K
中科院分区：
文献类型：
--
作者：
Jenkins LM;Horst B;Lancaster CL;Mythreye K
响应分泌生长因子的异常细胞信号传导与包括癌症在内的多种疾病的发展有关。因此，了解控制生长因子可用性和受体-生长因子相互作用的机制至关重要。双修饰跨膜蛋白聚糖（DMTPs）是一种由核心蛋白以共价连接的硫酸肝素（HS）和/或硫酸软骨素（CS）糖胺聚糖（GAG）链修饰而成的细胞表面大分子，提供了一种调节机制。具体来说，DMTPs β多糖和syndecan-1 （SDC1）在调节关键细胞信号通路（如Wnt、转化生长因子-β和成纤维细胞生长因子信号传导）中发挥关键作用，影响上皮细胞生物学和癌症进展。本文概述了β多糖和SDC1目前和潜在的功能，重点比较了HS和CS修饰的DMTPs的单独作用。我们强调了DMTPs的GAG链和核心蛋白的相互依赖性，并提供了这些DMTPs如何通过调节配体可用性和受体内化来控制参与发育和疾病的细胞信号通路的全面知识。
Aberrant cell signaling in response to secreted growth factors has been linked to the development of multiple diseases, including cancer. As such, understanding mechanisms that control growth factor availability and receptor-growth factor interaction is vital. Dually modified transmembrane proteoglycans (DMTPs), which are classified as cell surface macromolecules composed of a core protein decorated with covalently linked heparan sulfated (HS) and/or chondroitin sulfated (CS) glycosaminoglycan (GAG) chains, provide one type of regulatory mechanism. Specifically, DMTPs betaglycan and syndecan-1 (SDC1) play crucial roles in modulating key cell signaling pathways, such as Wnt, transforming growth factor-β and fibroblast growth factor signaling, to affect epithelial cell biology and cancer progression. This review outlines current and potential functions for betaglycan and SDC1, with an emphasis on comparing individual roles for HS and CS modified DMTPs. We highlight the mutual dependence of DMTPs’ GAG chains and core proteins and provide comprehensive knowledge on how these DMTPs, through regulation of ligand availability and receptor internalization, control cell signaling pathways involved in development and disease.
登录
查看更多内容
影响因子：
7.8
作者：
Ai, Xingbin;Do, Anh-Tri;Lozynska, Olga;Kusche-Gullberg, Marion;Lindahl, Ulf;Emerson, Charles P Jr
通讯作者：
Emerson, Charles P Jr
影响因子：
7.4
作者：
Bilir B;Kucuk O;Moreno CS
通讯作者：
Moreno CS
DOI：
10.1073/pnas.0901148106
发表时间：
2009-07-21
影响因子：
11.1
作者：
Chanana, Bhavna;Steigemann, Patrick;Vorbrueggen, Gerd
通讯作者：
Vorbrueggen, Gerd
DOI：
10.1016/j.bbamcr.2010.12.005
发表时间：
2011-02-01
影响因子：
5.1
作者：
Blair, Cheyne R.;Stone, Jacqueline B.;Wells, Rebecca G.
通讯作者：
Wells, Rebecca G.
影响因子：
4
作者：
Capurro, Mariana;Martin, Tonya;Filmus, Jorge
通讯作者：
Filmus, Jorge