COVID-19 Vaccines: Adenoviral Vectors.

COVID-19 Vaccines: Adenoviral Vectors.
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DOI:
10.1146/annurev-med-012621-102252
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发表时间:
2022-01-27
影响因子:
10.5
通讯作者:
Barouch DH
Barouch DH
中科院分区:
医学1区
文献类型:
--
作者:
Jacob-Dolan C;Barouch DH

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由严重急性呼吸道综合征冠状病毒2型(SARS-CoV-2)引起的2019年冠状病毒病(COVID-19)全球大流行导致多种疫苗的开发速度前所未有。这篇综述评估了如何利用腺病毒(Ad)载体平台来应对这一大流行病。Ad载体过去曾被用于对抗其他病毒的疫苗,最著名的是HIV和埃博拉病毒,但它们从未被如此大规模地生产、分发或施用于人类。已对编码SARS-CoV-2 Spike的几种不同血清型的Ad进行了测试,发现其对COVID-19有效。随着疫苗推广的继续以及接种这些疫苗的人数的增加,我们将继续了解这个疫苗平台以预防和控制COVID-19。
The worldwide pandemic of coronavirus disease 2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has led to the unprecedented pace of development of multiple vaccines. This review evaluates how adenovirus (Ad) vector platforms have been leveraged in response to this pandemic. Ad vectors have been used in the past for vaccines against other viruses, most notably HIV and Ebola, but they never have been produced, distributed, or administered to humans at such a large scale. Several different serotypes of Ads encoding SARS-CoV-2 Spike have been tested and found to be efficacious against COVID-19. As vaccine rollouts continue and the number of people receiving these vaccines increases, we will continue to learn about this vaccine platform for COVID-19 prevention and control.
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发表时间: 2018-03-15
影响因子: 5.4
作者:
Abbink P;Kirilova M;Boyd M;Mercado N;Li Z;Nityanandam R;Nanayakkara O;Peterson R;Larocca RA;Aid M;Tartaglia L;Mutetwa T;Blass E;Jetton D;Maxfield LF;Borducchi EN;Badamchi-Zadeh A;Handley S;Zhao G;Virgin HW;Havenga MJ;Barouch DH
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