SEX AND AGE-DIFFERENCES IN HUMAN PLATELET-AGGREGATION
SEX AND AGE-DIFFERENCES IN HUMAN PLATELET-AGGREGATION
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DOI：
10.1038/253355a0
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发表时间：
1975-01-01
期刊：
影响因子：
64.8
通讯作者：
RAMWELL, PW
中科院分区：
文献类型：
--
作者：
JOHNSON, M;RAMEY, E;RAMWELL, PW
男性在许多病理状态中存在风险1，特别是心血管疾病，其中男性的死亡率在统计学上显著高于女性2。我们描述了大鼠和豚鼠血小板反应性的性别差异，雄性血小板对聚集刺激的敏感性明显高于雌性。在人类、血栓栓塞性疾病4和急性心肌梗死5中检测到血小板反应性增加。事实上，突然死亡的受试者的主要死后发现是由于血小板聚集导致的肺循环阻塞6。我们已经证实3血小板敏感性是由雄激素类固醇介导的，雄激素有助于血栓性疾病的发生。
MALES stand at risk in many pathological states1, especially cardiovascular disease, in which there is a statistically significant higher mortality in men than women2. We have described3a sex difference in platelet responsivity in rats and guinea pigs where platelets from males were significantly more sensitive to aggregating stimuli than those from females. Increased platelet responsiveness has been detected in humans,in thromboembolic disease4and after acute myocardial infarction5. Indeed, the principalpost mortemfinding in subjects who died suddenly is occlusion in the pulmonary circulation due to platelet aggregation6. We have suggested3that platelet sensitivity is mediated by the androgenic steroids and that androgens contribute to the incidence of thrombotic disease.