Quality of life after radical prostatectomy or watchful waiting
Quality of life after radical prostatectomy or watchful waiting
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DOI：
10.1056/nejmoa021483
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发表时间：
2002-09-12
影响因子：
158.5
通讯作者：
Holmberg, L
中科院分区：
文献类型：
--
作者：
Steineck, G;Helgesen, F;Holmberg, L
背景资料：我们评估的症状和自我评估的生活质量的男性与局限性前列腺癌谁参加了根治性前列腺切除术和watchful waiting.Methods之间的随机比较：1989年和1999年，一组瑞典泌尿科医生随机分配的男性与局限性前列腺癌根治性前列腺切除术或watchful waiting。在这项随访研究中，我们从376名合格男性中的326名获得了信息（87%）通过邮寄问卷的方式，对某些症状、抑郁引起的痛苦、幸福感和生活质量的主观评估进行了调查。勃起功能障碍（80%对45%）和尿漏（49%对21%）在根治性膀胱切除术后更常见，而尿路梗阻（例如，28%对44%的弱尿流）不太常见。两组的肠功能、焦虑患病率、抑郁患病率、幸福感和主观生活质量相似。将患者分配到观察等待或根治性尿道切除术中会导致勃起功能障碍、尿漏和尿路梗阻的不同风险，但平均而言，在平均随访四年后，这种选择对幸福感或主观生活质量几乎没有任何影响。
Background: We evaluated symptoms and self-assessments of quality of life in men with localized prostate cancer who participated in a randomized comparison between radical prostatectomy and watchful waiting.Methods: Between 1989 and 1999, a group of Swedish urologists randomly assigned men with localized prostate cancer to radical prostatectomy or watchful waiting. In this follow-up study, we obtained information from 326 of 376 eligible men (87 percent) concerning certain symptoms, symptom-induced distress, well-being, and the subjective assessment of quality of life by means of a mailed questionnaire.Results: Erectile dysfunction (80 percent vs. 45 percent) and urinary leakage (49 percent vs. 21 percent) were more common after radical prostatectomy, whereas urinary obstruction (e.g., 28 percent vs. 44 percent for weak urinary stream) was less common. Bowel function, the prevalence of anxiety, the prevalence of depression, well-being, and the subjective quality of life were similar in the two groups.Conclusions: The assignment of patients to watchful waiting or radical prostatectomy entails different risks of erectile dysfunction, urinary leakage, and urinary obstruction, but on average, the choice has little if any influence on well-being or the subjective quality of life after a mean follow-up of four years.