1,1-Carboboration
1,1-Carboboration
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DOI：
10.1039/c1cc15628d
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发表时间：
2012-01-01
影响因子：
4.9
通讯作者：
Erker, Gerhard
中科院分区：
文献类型：
--
作者：
Kehr, Gerald;Erker, Gerhard
使用非常亲电的硼烷Rb(C6F5)(2)大大拓宽了1，1-碳硼化反应的范围。简单的末端炔烃HC CR在温和的条件下与RB(C6F5)(2)试剂快速反应，得到非常有用的新的烯基硼烷产品。甚至连内部的炔烃RC-CR也与Rb(C6F5)(2)试剂进行1，1-碳硼反应，从而提供了一种新的碳-碳西格键活化方法。这些反应的变体涉及磷取代炔烃和更复杂的双炔主基和过渡金属底物，在Rb(C6F5)(2)试剂处理下，通过涉及选择性1，1-碳硼化步骤的反应序列，导致非常有趣的官能化金属环产物的形成。
The use of very electrophilic boranes RB(C6F5)(2) widens the scope of the 1,1- carboboration reaction substantially. Simple terminal alkynes HC CR undergo this reaction with the RB(C6F5)(2) reagents rapidly under mild conditions to give high yields of very useful new alkenylborane products. Even internal alkynes RC CR undergo 1,1-carboboration with the RB(C6F5)(2) reagents to provide a novel way of carbon- carbon sigma-bond activation. Variants of these reactions involving phosphorus substituted alkynes and more complex bisalkynyl main group and transition metal substrates give rise to the formation of very interesting functionalized metallacyclic products upon treatment with RB(C6F5)(2) reagents by means of reaction sequences involving selective 1,1-carboboration steps.