Histologic analysis of alveolar bone following guided bone regeneration.
Histologic analysis of alveolar bone following guided bone regeneration.
复制标题
引导骨再生后牙槽骨的组织学分析。
DOI：
10.1902/jop.2004.75.5.750
复制
发表时间：
2004
影响因子：
4.3
通讯作者：
B. Leblebicioglu
中科院分区：
文献类型：
--
作者：
S. Ersanli;V. Olgaç;B. Leblebicioglu
背景
人们对使用各种移植材料进行引导骨再生（GBR）后的新骨质量及其在骨整合中的重要性提出了疑问。这项研究报告了对来自上颌和下颌未来植入部位的骨切片的组织学分析，这些骨切片用牛多孔骨矿物质移植材料和猪胶原膜增强。
方法
由于牙槽嵴严重萎缩，11 名患者（平均年龄 45.5 岁）在种植体植入前接受了 GBR。平均愈合时间为 7 个月后，进行了种植体植入手术。将来自种植床的骨切片固定在福尔马林中，在柠檬酸钠和甲酸中脱钙，并置于石蜡中。制备5至7微米厚的切片，用苏木精和曙红染色，并在光学显微镜下分析。给出了 27 个植入部位的结果。
结果
与下颌相比，上颌节段的骨骼百分比较低，残留材料和血管化的百分比较高。
结论
在本研究的范围内，我们得出结论，成骨已完成，血管形成率和破骨细胞活性降低了 7 个月。此外，上颌在骨形成、血管化和残留材料量方面与下颌显着不同。因此，缺损的解剖位置可能与使用引导骨再生技术获得成功成骨所使用的移植材料的特性一样重要。
BACKGROUND
Questions on new bone quality following guided bone regeneration (GBR) with various graft materials and its importance in osseointegration have been raised. This study reports histologic analysis of bone sections from future implant sites at upper and lower jaws that were augmented with bovine porous bone mineral graft material plus a porcine collagen membrane.
METHODS
Due to severe atrophy of the alveolar crest, GBR prior to implant placement was indicated in 11 patients (mean age 45.5 years). Following an average of 7 months of healing, implant placement surgery was performed. Bone sections from implant beds were fixed in formalin, decalcified in sodium citrate and formic acid, and placed in paraffin. Sections 5 to 7 microm thick were prepared, stained with hematoxylin and eosin, and analyzed under light microscopy. Results for 27 implant sites are presented.
RESULTS
Compared to the lower jaw, segments from the upper jaw had a lower percentage of bone and higher percentage of residual material and vascularization.
CONCLUSIONS
Within the limits of this study, we concluded that osteogenesis is completed and the rate of vascularization and osteoclastic activity was reduced by 7 months. Also, the upper jaw significantly differed from the lower jaw in bone formation, vascularization, and the amount of residual material. Thus, the anatomical location of the defect may be as important as the properties of the graft material used in obtaining successful osteogenesis using guided bone regeneration techniques.