Ventilatory chemoresponsiveness, narcolepsy-cataplexy and human leukocyte antigen DQB1☆0602 status
Ventilatory chemoresponsiveness, narcolepsy-cataplexy and human leukocyte antigen DQB1☆0602 status
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DOI：
10.1183/09031936.00174609
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发表时间：
2010-09-01
影响因子：
24.3
通讯作者：
Strohl, K. P.
中科院分区：
文献类型：
--
作者：
Han, F.;Mignot, E.;Strohl, K. P.
我们假设下丘脑泌素（食欲素）在决定化疗敏感性中起作用。招募130名发作性睡病-癫痫患者（平均+/- SD年龄20 +/-10岁，69%男性）和117名对照（22 +/-6.9岁，62%男性），并测试人类白细胞抗原（HLA）-DQB 1（星星）0602状态、高氧高碳酸血症（每分钟通气量（Δ V ′ E）/二氧化碳分压（Δ PCO 2）L.min（-1.）mmHg（-1））和缺氧（Δ V ′ E/通过探头血氧测定法（Δ Sp，O-2）L.min（-1）/ % Sp，O-2）反应性和通过肺活量测定法测量的动脉氧饱和度变化。下丘脑泌素缺乏症通过测量脑脊液下丘脑泌素-1（37例患者）或通过阳性HLA-DQB 1（星星）0602状态确定。所有患者和49%的对照组进行了多导睡眠图和多次睡眠潜伏期测试。尽管肺功能测定值相似，但患者的呼吸暂停/呼吸不足指数（AHI）较高（2.8 +/- 5.4 vs 0.8 +/- 1.6 h（-1）; p=0.03），睡眠时最低血氧饱和度较低（87%+/- 7 vs 91 +/- 4%; p=0.0002），与年龄、性别和体重指数无关。患者的低氧反应性降低（每% Sp，O-2为0.13 +/- 0.09 vs 0.19 +/- 0.13 L.min（-1）; p
We hypothesised that hypocretin (orexin) plays a role in the determination of ventilatory chemosensitivity. 130 patients with narcolepsy-cataplexy (mean +/- SD age 20 +/- 10 yrs, 69% male) and 117 controls (22 +/- 6.9 yrs, 62% male) were recruited and tested for human leukocyte antigen (HLA)-DQB1(star)0602 status, hyperoxia hypercapnic (change in minute ventilation (Delta V'E)/carbon dioxide tension (Delta PCO2) L.min(-1.)mmHg(-1)) and hypoxic (Delta V'E /change in arterial oxygen saturation measured by probe oximetry (Delta Sp,O-2) L.min(-1) per % Sp,O-2) responsiveness, and by spirometry. Hypocretin deficiency was determined either by measures of cerebrospinal fluid hypocretin-1 (37 patients) or by positive HLA-DQB1(star)0602 status. All patients and 49% of controls underwent polysomnography and multiple sleep latency testing. Despite similar spirometric values, patients had a higher apnoea/hypopnoea index (AHI) (2.8 +/- 5.4 versus 0.8 +/- 1.6 h(-1); p=0.03) and lower minimal oxygen saturation during sleep (87%+/- 7 versus 91 +/- 4%; p=0.0002), independent of age, sex and body mass index. Patients had depressed hypoxic responsiveness (0.13 +/- 0.09 versus 0.19 +/- 0.13 L.min(-1) per % Sp,O-2; p