Primary induction of human CD8+ cytotoxic T lymphocytes and interferon-γ-producing T cells after smallpox vaccination
Primary induction of human CD8+ cytotoxic T lymphocytes and interferon-γ-producing T cells after smallpox vaccination
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DOI：
10.1086/340517
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发表时间：
2002-06-01
影响因子：
6.4
通讯作者：
McClain, DJ
中科院分区：
文献类型：
--
作者：
Ennis, FA;Cruz, J;McClain, DJ
这项研究测量了通过划痕（用分叉针）给予的标准天花疫苗诱导原代人痘苗病毒特异性细胞毒性和产生干扰素 (IFN) 的 T 淋巴细胞反应的能力。由于针对天花的保护可能部分是由疫苗接种诱导的 T 细胞记忆反应介导的，因此对原代人细胞毒性 T 淋巴细胞 (CTL) 和产生 IFN-γ 的 T 细胞反应的诱导进行了分析。尽管天花在自然条件下不再是流行病威胁，但仍然建议在实验室中处理痘苗病毒的人员以及可能面临天花病毒作为生物恐怖主义制剂使用风险的人员接种疫苗。结果表明，通过分叉针注射天花疫苗可诱导强烈的痘苗病毒特异性 CD8(+) CTL 和产生 IFN-γ 的 T 细胞反应，并为规划未来天花疫苗的免疫学评估提供有用的基线信息。
This study measured the ability of a standard smallpox vaccine, given by scarification (by bifurcated needle), to induce primary human vaccinia virus-specific cytotoxic and interferon (IFN)-gamma-producing T lymphocyte responses. Because protection against smallpox may be mediated in part by T cell memory responses induced by vaccination, an analysis of the induction of primary human cytotoxic T lymphocytes (CTL) and IFN-gamma-producing T cell responses was performed. Although smallpox is no longer an epidemic threat under natural conditions, vaccination is still recommended for persons working with vaccinia viruses in the laboratory and for those who may be at risk from the potential use of smallpox virus as a bioterrorism agent. The results demonstrate that smallpox vaccine given by bifurcated needle induces strong vaccinia virus-specific CD8(+) CTL and IFN-gamma-producing T cell responses and provide baseline information useful for planning the immunologic assessment of future smallpox vaccines.