Chemical Composition and Anticancer and Antioxidant Activities of Schinus Molle L. and Schinus Terebinthifolius Raddi Berries Essential Oils
Chemical Composition and Anticancer and Antioxidant Activities of Schinus Molle L. and Schinus Terebinthifolius Raddi Berries Essential Oils
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DOI：
10.1111/j.1750-3841.2010.01711.x
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发表时间：
2010-08-01
影响因子：
3.9
通讯作者：
Bouajila, Jalloul
中科院分区：
文献类型：
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作者：
Bendaoud, Houcine;Romdhane, Mehrez;Bouajila, Jalloul
通过水蒸气蒸馏法从原产于突尼斯南部的 Schinus molle L. 和 Schinus terebinthifolius Raddi 的浆果中获得精油，并通过 GC-FID 和 GC-MS 进行分析。在这些油中鉴定出的 57 和 62 种化合物（% [mg/100 g 干物质]）中，主要是 α-水芹烯（46.52% [1256.15] 和 34.38% [859.60]）、β-水芹烯（20.81% [561.74] 和 10.61% [265.15]）、α-萜品醇(8.38% [226.26] 和 5.60% [140.03])、α-蒎烯 (4.34% [117.29] 和 6.49% [162.25])、β-蒎烯 (4.96% [133.81] 和 3.09% [77.30]) 和对伞花烃 (2.49% [67.28] 和7.34% [183.40]）。在 S. terebinthifolius 精油中还发现了显着量的 γ-杜松烯 (18.04% [451.05])，而在 S. molle 精油中仅检测到痕量 (0.07% [1.81])。通过使用 1,1-二苯基-2-三硝苯肼 (DPPH) 和 2,2'-Azinobis(3-乙基苯并噻唑啉-6-磺酸) (ABTS) 测定法评估所研究精油的体外抗氧化和抗自由基清除特性。与 S. molle 相比，S. terebinthifolius 精油在 ABTS 测定中表现出更强的抗氧化活性，IC50 为 24 +/- 0.8 mg/L（IC50 = 257 +/- 10.3 mg/L）。还评估了精油对人类乳腺癌细胞（MCF-7）的抗癌活性。 S. terebinthifolius 精油对测试细胞系 (IC50 = 47 +/- 9 mg/L) 比 S. molle 精油 (IC50 = 54 +/- 10 mg/L) 更有效。概述了有关化学成分和生物活性之间关系的建议。
Essential oils were obtained by steam distillation from berries of Schinus molle L. and Schinus terebinthifolius Raddi originating from southern of Tunisia and analyzed by GC-FID and GC-MS. Among 57 and 62 compounds (% [mg/100 g dry matter]) identified in these oils, the main were a-phellandrene (46.52% [1256.15] and 34.38% [859.60]), beta-phellandrene (20.81% [561.74] and 10.61% [265.15]), alpha-terpineol (8.38% [226.26] and 5.60% [140.03]), alpha-pinene (4.34% [117.29] and 6.49% [162.25]), beta-pinene (4.96% [133.81] and 3.09% [77.30]) and p-cymene (2.49% [67.28] and 7.34% [183.40]), respectively. A marked quantity of gamma-cadinene (18.04% [451.05]) was also identified in the S. terebinthifolius essential oil whereas only traces (0.07% [1.81]) were detected in the essential oil of S. molle. The in vitro antioxidant and antiradical scavenging properties of the investigated essential oils were evaluated by using 1,1-diphenyl-2-picrylhydrazyl (DPPH) and 2,2'-Azinobis(3-ethylbenzothiazoline-6-sulfonic acid) (ABTS) assays. Essential oil of S. terebinthifolius expressed stronger antioxidant activity in the ABTS assay, with an IC50 of 24 +/- 0.8 mg/L, compared to S. molle (IC50 = 257 +/- 10.3 mg/L). Essential oils were also evaluated for their anticancer activities against human breast cancer cells (MCF-7). S. terebinthifolius essential oil was more effective against tested cell lines (IC50 = 47 +/- 9 mg/L) than that from S. molle (IC50 = 54 +/- 10 mg/L). Suggestions on relationships between chemical composition and biological activities are outlined.