The association between dioxins and steroid hormones in general adult males: a cross-sectional study in an e-waste region of China
The association between dioxins and steroid hormones in general adult males: a cross-sectional study in an e-waste region of China
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DOI：
10.1007/s11356-020-09086-4
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发表时间：
2020-05
影响因子：
5.8
通讯作者：
L. Shi;Mei Qin Wang;S. Nakayama;Chau-Ren Jung;Yue Hua Wang;Jingjian Dong;Chaochen Ma;T. Kido
中科院分区：
文献类型：
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作者：
L. Shi;Mei Qin Wang;S. Nakayama;Chau-Ren Jung;Yue Hua Wang;Jingjian Dong;Chaochen Ma;T. Kido
在电子垃圾(电子垃圾)回收区的居民中观察到，二恶英可以破坏内分泌激素的动态平衡和甲状腺激素的平衡。然而，很少有研究研究电子垃圾回收活动是否会影响普通成年男性人群的类固醇激素平衡。这项研究评估了居住在电子垃圾地区的普通成年男性人群中类固醇激素与二恶英的身体负担之间的关系。2017年9月，74名居住在电子垃圾拆解地区的成年男性参加了本研究。从每个成年男性身上采集大约10毫升的血液，并通过离心法分离血清样本。然后，测定参与者血清中的二恶英和类固醇激素水平。我们根据四分位数(25、50和75%)将二恶英水平视为一般线性模型中的分类变量。与参照组(第25百分位数)比较，我们注意到，在血清多氯二苯并呋喃毒性当量(PCDFS-TEQ)水平在3.80至6.31 pg/g脂肪(1933对1447 pg/ml)和低多氯二苯并-对二恶英和二苯并呋喃-TEQ(PCDD/PCDFS-TEQ)在8.57至15.11 pg/g脂肪(1996对1360 pg/ml)之间的男性中，脱氢表雄酮(DHEA)水平显著高于对照组。此外，在血清PCDFS-TEQ≥11.34pg/g LIPD的男性中发现显著更高的雄烯二酮(A-Dione)水平(2404vs.1848)。此外，2，3，7，8-四氯二苯并-对二恶英(TCDD)低剂量组和高剂量组的3-β-羟基类固醇脱氢酶(3-β-HSD)浓度分别为719和807pg-TEQ/g脂肪，≥为2.64pg-TEQ/g脂肪，差异有统计学意义(P<0.05)。我们的研究结果表明，在中国电子垃圾地区，特定的二恶英暴露可能会扰乱正常成年男性人群的脱氢表雄酮、A-二酮水平和酶活性。
As observed among residents in electronic waste (e-waste) recycling areas, dioxins can disrupt the homeostasis of endocrine hormones and the balance of thyroid hormones. Few studies, however, have examined whether e-waste recycling activities influence steroid hormone equilibrium in the general adult male population. This study evaluated the association between steroid hormones and the physical burdens of dioxins in the general adult male population residing in an e-waste region. In September 2017, 74 adult males residing in an e-waste dismantling region were enrolled in the current study. Approximately 10 mL of blood was collected from each adult male, and the serum samples were separated through centrifugation. Then, the levels of dioxin and steroid hormones in the serum of the participants were measured. We treated dioxin levels as categorical variables in the general linear model according to quartiles (25, 50, and 75 percentile). Comparing the findings with a reference group (< 25th percentile), we noted significantly higher dehydroepiandrosterone (DHEA) level in men with low serum polychlorinated dibenzofuran-toxic equivalent (PCDFs-TEQ) level between 3.80 and 6.31 pg/g lipid (1933 vs. 1447 pg/ml) and low polychlorinated dibenzo-p-dioxins and dibenzofurans-TEQ (PCDD/PCDFs-TEQ) between 8.57 and 15.11 pg/g lipid (1996 vs. 1360 pg/ml). Moreover, a significantly higher androstenedione (A-dione) level was found in men whose serum PCDFs-TEQ ≥ 11.34 pg/g lipd (2404 vs. 1848). What’s more, there were significantly higher 3β-hydroxysteroid dehydrogenase (3β-HSD) concentrations in low- and high-2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) groups (1.30–1.67 and ≥ 2.64 pg-TEQ/g lipid, respectively with 719 and 807 vs. 496, respectively). Our findings suggest that specific dioxin exposure may disturb normal DHEA, A-dione levels, and enzyme activity in the general adult male population in an e-waste region of China.