Decreased cortical glucose metabolism correlates with hippocampal atrophy in Alzheimer's disease as shown by MRI and PET.
Decreased cortical glucose metabolism correlates with hippocampal atrophy in Alzheimer's disease as shown by MRI and PET.
复制标题
MRI 和 PET 显示，皮质葡萄糖代谢下降与阿尔茨海默病中的海马萎缩有关。
DOI：
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发表时间：
1997
影响因子：
11
通讯作者：
A. Yamadori
中科院分区：
文献类型：
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作者：
S. Yamaguchi;K. Meguro;M. Itoh;C. Hayasaka;M. Shimada;H. Yamazaki;A. Yamadori
目的：探讨阿尔茨海默病海马和海马旁回（海马面积%）萎缩与脑葡萄糖代谢率（CMRGlc）的关系。方法：选取符合NINCDS-ADRDA标准的13例疑似阿尔茨海默病患者（男6例，女7例，平均年龄71岁，精神状态为13.8 (SD 4.6)）和年龄匹配的对照组。采用T1加权MRI （0.5T）图像对海马区进行评估。利用数字化系统，计算海马区占大脑的百分比（海马区百分比）。8例患者再次接受T1加权MRI (1.5T)，进一步评估海马的最小厚度。采用PET和FDG技术测定区域CMRGlc （rCMRGlc）。结果：阿尔茨海默病患者海马区明显低于对照组（P < 0.01）。阿尔茨海默病患者皮质rCMRGlc值均低于对照组（P < 0.01）。阿尔茨海默病海马区与颞叶、颞顶枕（TPO）区、额叶rCMRGlc呈显著相关（P < 0.05）。海马最小厚度与两侧同侧TPO代谢有显著相关性。结论：阿尔茨海默病海马萎缩与TPO代谢减少的同侧相关性提示功能关系，不对称性提示阿尔茨海默病早期是一种不对称疾病。
OBJECTIVE: To investigate the relation between atrophy of the hippocampus and parahippocampal gyrus (the % hippocampal area) and cerebral metabolic rate for glucose (CMRGlc) in Alzheimer's disease. METHODS: 13 patients with probable Alzheimer's disease by NINCDS-ADRDA criteria (six men; seven women, mean age 71 years, mini mental state 13.8 (SD 4.6)) and age matched controls were studied. T1 weighted MRI (0.5T) images were used for evaluation of the hippocampal area. With a digitiser system, a percentage of the hippocampal area to the brain (the % hippocampal area) was calculated. Eight patients received another T1 weighted MRI (1.5T) for further evaluation of the minimum thickness of the hippocampus. Regional CMRGlc (rCMRGlc) was measured using PET and the FDG technique. RESULTS: The hippocampal area in patients with Alzheimer's disease was significantly lower than that of controls (P < 0.01). All the cortical rCMRGlc values in patients with Alzheimer's disease were lower than those of controls (P < 0.01). A significant correlation (P < 0.05) was found between the % hippocampal area and rCMRGlc in the temporal lobe, temporoparieto-occipital (TPO) region, and frontal lobe in Alzheimer's disease. There was a significant correlation between minimal hippocampal thickness and ipsilateral TPO metabolism on both sides. CONCLUSION: The ipsilateral correlation between hippocampal atrophy and decreased TPO metabolism in Alzheimer's disease suggests a functional relation and the asymmetries show that Alzheimer's disease is an asymmetric disease in its early stages.
阿尔茨海默氏型早老性痴呆患者的心室大小。
影响因子：
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作者：
Albert,M;Naeser,MA;Levine,HL;Garvey,AJ
通讯作者：
Garvey,AJ