Stress in Regulation of GABA Amygdala System and Relevance to Neuropsychiatric Diseases.

Stress in Regulation of GABA Amygdala System and Relevance to Neuropsychiatric Diseases.
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GABA 杏仁核系统的调节压力及其与神经精神疾病的相关性

DOI:
10.3389/fnins.2018.00562
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发表时间:
2018
影响因子:
4.3
通讯作者:
Li B
Li B
中科院分区:
医学2区
文献类型:
--
作者:
Jie F;Yin G;Yang W;Yang M;Gao S;Lv J;Li B

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杏仁核是一个杏仁状的核团,位于颞叶深处,被认为在调节情绪过程中起着至关重要的作用。GABA能神经传递抑制杏仁核,防止我们产生不适当的情绪和行为反应。应激可导致GABA能神经元间网络的减少和神经心理疾病的发生。本文综述了GABA能对杏仁核的调控及其与急性和慢性应激的相互作用的可能机制。总之,这项研究可能有助于未来的进展,找到新的方法来扭转杏仁核中的应激诱导的GABA能神经传递的衰减。
The amygdala is an almond-shaped nucleus located deep and medially within the temporal lobe and is thought to play a crucial role in the regulation of emotional processes. GABAergic neurotransmission inhibits the amygdala and prevents us from generating inappropriate emotional and behavioral responses. Stress may cause the reduction of the GABAergic interneuronal network and the development of neuropsychological diseases. In this review, we summarize the recent evidence investigating the possible mechanisms underlying GABAergic control of the amygdala and its interaction with acute and chronic stress. Taken together, this study may contribute to future progress in finding new approaches to reverse the attenuation of GABAergic neurotransmission induced by stress in the amygdala.
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