Stress in Regulation of GABA Amygdala System and Relevance to Neuropsychiatric Diseases.
Stress in Regulation of GABA Amygdala System and Relevance to Neuropsychiatric Diseases.
复制标题
GABA 杏仁核系统的调节压力及其与神经精神疾病的相关性
DOI:
10.3389/fnins.2018.00562
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发表时间:
2018
影响因子:
4.3
通讯作者:
Li B
中科院分区:
文献类型:
--
作者:
Jie F;Yin G;Yang W;Yang M;Gao S;Lv J;Li B
The amygdala is an almond-shaped nucleus located deep and medially within the temporal lobe and is thought to play a crucial role in the regulation of emotional processes. GABAergic neurotransmission inhibits the amygdala and prevents us from generating inappropriate emotional and behavioral responses. Stress may cause the reduction of the GABAergic interneuronal network and the development of neuropsychological diseases. In this review, we summarize the recent evidence investigating the possible mechanisms underlying GABAergic control of the amygdala and its interaction with acute and chronic stress. Taken together, this study may contribute to future progress in finding new approaches to reverse the attenuation of GABAergic neurotransmission induced by stress in the amygdala.
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