Synergistic activation of transcription is mediated by the N-terminal domain of Drosophila fushi tarazu homeoprotein and can occur without DNA binding by the protein.
Synergistic activation of transcription is mediated by the N-terminal domain of Drosophila fushi tarazu homeoprotein and can occur without DNA binding by the protein.
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转录的协同激活是由果蝇 fushi tarazu 同源蛋白的 N 末端结构域介导的，并且无需该蛋白与 DNA 结合即可发生。
DOI：
10.1128/mcb.13.3.1599-1609.1993
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发表时间：
1993
影响因子：
5.3
通讯作者：
Voellmy,R
中科院分区：
文献类型：
--
作者：
Ananthan,J;Baler,R;Morrissey,D;Zuo,J;Lan,Y;Weir,M;Voellmy,R
Synergistic activation of transcription byDrosophilasegmentation genes in tissue culture cells provides a model with which to study combinatorial regulation. We examined the synergistic activation of anengrailed-derived promoter by the pair-rule proteins paired (PRD) and fushi tarazu (FTZ). Synergistic activation by PRD requires regions of the homeodomain or adjacent sequences, and that by FTZ requires the first 171 residues. Surprisingly, deletion of the FTZ homeodomain does not reduce the capacity of the protein for synergistic activation, although this mutation abolishes any detectable DNA-binding activity. This finding suggests that FTZ can function through protein-protein interactions with PRD or other components of the homeoprotein transcription complex, adding a new layer of mechanisms that could underlie the functional specificities and combinatorial regulation of homeoproteins.
