Keep in contact: multiple roles of endoplasmic reticulum-membrane contact sites and the organelle interaction network in plants.
Keep in contact: multiple roles of endoplasmic reticulum-membrane contact sites and the organelle interaction network in plants.
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保持接触：植物中内质网-膜接触位点和细胞器相互作用网络的多重作用。
DOI：
10.1111/nph.18745
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发表时间：
2023
期刊：
影响因子：
--
通讯作者：
Wang P
中科院分区：
文献类型：
--
作者：
Wang P
植物不同细胞器的功能调节和结构维持直接影响植物的发育、繁殖和逆境响应。为了确保这些活动有效地进行，细胞在各种亚细胞区室之间进化出一个相互连接的网络，调节快速的信号转导和生物材料的交换。最近在植物中鉴定出许多调节膜连接的蛋白质，这是阐明这些连接的机制和功能的第一步。在所有的细胞器中，内质网是关键的结构，它可能通过膜接触位点（MCS）和ER-PM接触位点（EPCS）连接大多数不同的亚细胞区室已经在植物中得到了最深入的研究。然而，植物MCS的分子组成和功能被发现不同于其他真核系统。在本文中，我们将总结这一领域的最新进展，并讨论这些重要环节在植物中的机制和生物学意义。
Functional regulation and structural maintenance of the different organelles in plants contribute directly to plant development, reproduction and stress responses. To ensure these activities take place effectively, cells have evolved an interconnected network amongst various subcellular compartments, regulating rapid signal transduction and the exchange of biomaterial. Many proteins that regulate membrane connections have recently been identified in plants, and this is the first step in elucidating both the mechanism and function of these connections. Amongst all organelles, the endoplasmic reticulum is the key structure, which likely links most of the different subcellular compartments through membrane contact sites (MCS) and the ER–PM contact sites (EPCS) have been the most intensely studied in plants. However, the molecular composition and function of plant MCS are being found to be different from other eukaryotic systems. In this article, we will summarise the most recent advances in this field and discuss the mechanism and biological relevance of these essential links in plants.