Development, growth, propagation, and angiographic utilization of the rabbit VX2 model of liver cancer: a pictorial primer and "how to" guide
Development, growth, propagation, and angiographic utilization of the rabbit VX2 model of liver cancer: a pictorial primer and "how to" guide
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DOI：
10.5152/dir.2014.13415
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发表时间：
2014-07-01
影响因子：
2.1
通讯作者：
Gaba, Ron C.
中科院分区：
文献类型：
--
作者：
Parvinian, Ahmad;Casadaban, Leigh C.;Gaba, Ron C.
VX2肿瘤是一种间变性鳞状细胞癌，其特征是生长迅速，血管丰富，在骨骼肌中易于扩散。自70多年前提出以来，它已被用于各种恶性肿瘤的模型，并通常被介入放射科医生用于肝细胞癌的临床前研究。然而，尽管这种模式受到了广泛而持久的欢迎，但几乎没有技术资源详细说明它的用途。本文对兔VX2肝肿瘤模型的发展、生长、繁殖和血管造影应用的技术方法进行了全面的图示概述。
The VX2 tumor is a leporine anaplastic squamous cell carcinoma characterized by rapid growth, hypervascularity, and facile propagation in the skeletal muscle. Since its introduction over 70 years ago, it has been used to model a variety of malignancies, and is commonly employed by interventional radiologists in preclinical investigations of hepatocellular carcinoma. However, despite the widespread and lasting popularity of the model, there are few technical resources detailing its use. Herein, we present a comprehensive pictorial outline of the technical methodology for development, growth, propagation, and angiographic utilization of the rabbit VX2 liver tumor model.