Biosynthesis of tetronate antibiotics: A growing family of natural products with broad biological activities
Biosynthesis of tetronate antibiotics: A growing family of natural products with broad biological activities
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DOI：
10.1007/s11426-013-4921-x
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发表时间：
2013-08
期刊：
影响因子：
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通讯作者：
Weixin Tao;Manghong Zhu;Z. Deng;Yuhui Sun
中科院分区：
文献类型：
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作者：
Weixin Tao;Manghong Zhu;Z. Deng;Yuhui Sun
特窗酸类抗生素是一类以特窗酸为特征的天然产物，由于其典型的结构，特别是螺特窗酸结构，以及相应的多功能生物活性而备受关注。自从第一个特连二酸被分离出来以来，通过同位素标记的饲养实验、生物合成基因簇的遗传学表征和关键酶催化反应的生物化学重建，一直在进行相当大的努力来阐明天然特连二酸产物的生物合成。因此，螺替膦酸酯的生物合成已逐渐确定，包括螺替膦酸酯糖苷配基的聚酮衍生骨架的生物合成，甘油衍生的三碳单元掺入到特窗酸部分中，通过Diels-Alder样反应形成成熟糖苷配基，以及用各种脱氧糖部分修饰糖苷配基。本文详细介绍了天然四酮化合物的生物合成研究，并相应总结了这类天然产物的常见生物合成途径。
Tetronate antibiotics, a growing family of natural products featuring a characteristic tetronic acid moiety, are of importance and of particular interest for their typical structures, especially the spirotetronate structure, and corresponding versatile biological activities. Considerable efforts have persistently performed since the first tetronate was isolated, to elucidate the biosynthesis of natural tetronate products, by isotope-labeled feeding experiments, genetical characterization of biosynthetic gene clusters, and biochemical reconstitution of key enzymatic catalyzed reactions. Accordingly, the biosynthesis of spirotetronates has been gradually determined, including biosynthesis of a polyketide-derived backbone for spirotetronate aglycone, incorporation of a glycerol-derived three-carbon unit into tetronic acid moiety, formation of mature aglycone via Diels-Alder-like reaction, and decorations of aglycone with various deoxysugar moieties. In this paper, the biosynthetic investigations of natural tetronates are well documented and a common biosynthetic route for this group of natural products is summarized accordingly.