Translation of the phosphoinositide code by PI effectors.
Translation of the phosphoinositide code by PI effectors.
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DOI：
10.1038/nchembio.390
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发表时间：
2010-07
影响因子：
14.8
通讯作者：
Kutateladze TG
中科院分区：
文献类型：
--
作者：
Kutateladze TG
磷脂酰肌醇（PI）脂质是真核细胞膜的重要组成部分。它们通过磷脂酰肌醇（PtdIns）的肌醇头基的单磷酸化、双磷酸化和三磷酸化产生，并浓缩在细胞溶质膜的单独池中。PI作为细胞区室的标记物，并形成蛋白质效应物的独特对接位点。总的来说，七种已知的PI，结合它们的蛋白质效应物和产生或修饰PI的酶组成了一个非常复杂的蛋白质-脂质信号网络。许多胞质蛋白含有一个或几个能够识别单个PI并将宿主蛋白募集到不同细胞内区室的效应子模块。最近确定的原子分辨率的结构和膜靶向机制的十几PI效应提供了深入的了解内吞膜运输和信号调节的分子基础。在这篇评论中，我强调的结构方面的破译的“PI代码”的最常见的PI识别效应器，并讨论其膜锚定的机械细节。
Phosphoinositide (PI) lipids are essential components of eukaryotic cell membranes. They are produced by mono-, bis- and trisphosphorylation of the inositol headgroup of phosphatidylinositol (PtdIns) and are concentrated in separate pools of cytosolic membranes. PIs serve as markers of the cell compartments and form unique docking sites for protein effectors. Collectively, seven known PIs, the protein effectors that bind them and enzymes that generate or modify PIs compose a remarkably complex protein-lipid signaling network. A number of cytosolic proteins contain one or several effector modules capable of recognizing individual PIs and recruiting the host proteins to distinct intracellular compartment. The recently determined atomic-resolution structures and membrane-targeting mechanisms of a dozen PI effectors have provided insights into the molecular basis for regulation of endocytic membrane trafficking and signaling. In this review, I highlight the structural aspects of the deciphering of the ‘PI code’ by the most common PI-recognizing effectors and discuss the mechanistic details of their membrane anchoring.
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