Significant association of increased PD-L1 and PD-1 expression with nodal metastasis and a poor prognosis in oral squamous cell carcinoma
Significant association of increased PD-L1 and PD-1 expression with nodal metastasis and a poor prognosis in oral squamous cell carcinoma
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DOI：
10.1016/j.ijom.2018.01.004
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发表时间：
2018-07-01
影响因子：
2.4
通讯作者：
Nakamura, S.
中科院分区：
文献类型：
--
作者：
Maruse, Y.;Kawano, S.;Nakamura, S.
程序性细胞死亡配体1 （PD-L1）及其受体PD-1是免疫检查点分子，可减弱免疫反应。阻断PD-L1可增强多种肿瘤的免疫应答，从而作为一种有效的抗癌治疗方法。然而，PD-L1/PD-1信号在口腔鳞状细胞癌（OSCC）中的生物学和预后作用仍有待阐明。本研究的目的是研究PD-L1/PD-1信号传导与OSCC患者预后的相关性，以评估其潜在的治疗相关性。应用免疫组织化学方法检测97例OSCC患者中PD-L1和PD-1的表达，并探讨其表达与临床病理特征的关系。64.9%的OSCC病例中PD-L1表达升高，61.9%的OSCC病例中PD-1表达升高。单因素和多因素分析显示，PD-L1和PD-1表达升高与颈淋巴结转移呈正相关。活化t细胞标志物CD25的表达与PD-L1和PD-1的标记指数呈负相关。此外，pd - l1阳性和pd -1阳性表达的患者组比pd - l1阴性和pd -1阴性表达的患者预后更不利。这些数据表明，PD-L1和PD-1表达的增加预示着淋巴结转移和预后不良，并可能通过减弱免疫反应参与癌症进展。
Programmed cell death ligand 1 (PD-L1) and its receptor PD-1 are immune checkpoint molecules that attenuate the immune response. Blockade of PD-L1 enhances the immune response in a variety of tumours and thus serves as an effective anti-cancer treatment. However, the biological and prognostic roles of PD-L1/PD-1 signalling in oral squamous cell carcinoma (OSCC) remain to be elucidated. The purpose of this study was to examine the correlation of PD-L1/PD-1 signalling with the prognosis of OSCC patients to assess its potential therapeutic relevance. The expression of PD-L1 and of PD-1 was determined immunohistochemically in 97 patients with OSCC and the association of this expression with clinicopathological characteristics was examined. Increased expression of PD-L1 was found in 64.9% of OSCC cases and increased expression of PD-1 was found in 61.9%. Univariate and multivariate analysis revealed that increased expression of PD-L1 and PD-1 positively correlated with cervical lymph node metastasis. The expression of CD25, an activated T-cell marker, was negatively correlated with the labelling index of PD-L1 and PD-1. Moreover, the patient group with PD-L1-positive and PD-1-positive expression showed a more unfavourable prognosis than the group with PD-L1-negative and PD-1-negative expression. These data suggest that increased PD-L1 and PD-1 expression is predictive of nodal metastasis and a poor prognosis and is possibly involved in cancer progression via attenuating the immune response.