PRETREATMENT NUTRITIONAL STATUS AND LOCOREGIONAL FAILURE IN PATIENTS WITH HEAD AND NECK CANCER UNDERGOING DEFINITIVE CONCURRENT CHEMORADIATION THERAPY
PRETREATMENT NUTRITIONAL STATUS AND LOCOREGIONAL FAILURE IN PATIENTS WITH HEAD AND NECK CANCER UNDERGOING DEFINITIVE CONCURRENT CHEMORADIATION THERAPY
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DOI：
10.1002/hed.21640
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发表时间：
2011-11-01
影响因子：
2.9
通讯作者：
Singh, Anurag K.
中科院分区：
文献类型：
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作者：
Platek, Mary E.;Reid, Mary E.;Singh, Anurag K.
背景。本研究的目的是确定营养状况标志物是否可以预测头颈鳞状细胞癌 (SCCHN) 调强放射治疗 (IMRT) 联合同步放化疗 (CCRT) 后的局部失败。方法。我们对 78 名接受明确 CCRT 的 SCCHN 患者进行了回顾性图表审查。我们比较了有和没有局部区域衰竭患者的患者因素、肿瘤特征和营养状况指标。结果。 78 名患者中有 15 名 (19%) 经历了局部区域衰竭。活体患者的中位随访时间为 38 个月。在单变量分析中，治疗前理想体重百分比 (%IBW) (p < .01)、治疗前血红蛋白 (p = .04) 和治疗持续时间 (p < .01) 是失败的显着预测因子。在多变量分析中，治疗前 %IBW (p = .04) 和治疗时间 (p < .01) 仍然具有统计学显着性。结论。尽管治疗时间是公认的失败风险因素，但应进一步检查接受基于治疗前 %IBW 的确定性 CCRT 的头颈癌患者的结果差异。 (C) 2010 Wiley periodicals, Inc. Head Neck 33: 1561-1568, 2011
Background. This study was carried out to determine if markers of nutritional status predict for locoregional failure following intensity-modulated radiation therapy (IMRT) with concurrent chemoradiotherapy (CCRT) for squamous cell carcinoma of the head and neck (SCCHN).Methods. We performed a retrospective chart review of 78 patients with SCCHN who received definitive CCRT. We compared patient factors, tumor characteristics, and nutritional status indicators between patients with and without locoregional failure.Results. Fifteen of 78 patients (19%) experienced locoregional failure. Median follow-up for live patients was 38 months. On univariate analysis, pretreatment percentage of ideal body weight (%IBW) (p < .01), pretreatment hemoglobin (p = .04), and treatment duration (p < .01) were significant predictors of failure. On multivariate analysis, pretreatment %IBW (p = .04) and treatment time (p < .01) remained statistically significant.Conclusions. Although treatment time is an accepted risk factor for failure, differences in outcome for patients with head and neck cancer undergoing definitive CCRT based on pretreatment %IBW should be examined further. (C) 2010 Wiley Periodicals, Inc. Head Neck 33: 1561-1568, 2011