Intra-coronary administration of cyclosporine limits infarct size, attenuates remodeling and preserves left ventricular function in porcine acute anterior infarction
Intra-coronary administration of cyclosporine limits infarct size, attenuates remodeling and preserves left ventricular function in porcine acute anterior infarction
复制标题
DOI：
10.1016/j.ijcard.2009.08.008
复制
发表时间：
2011-02-17
影响因子：
3.5
通讯作者：
Yip, Hon-Kan
中科院分区：
文献类型：
--
作者：
Sheu, Jiunn-Jye;Chua, Sarah;Yip, Hon-Kan
背景：我们测试了冠状动脉内注射环孢素是否能有效地保护猪急性前壁梗死（AMI）患者的左心室（LV）功能。方法与结果：18头雄性小型猪随机分为1组（对照组）、2组（AMI单独治疗组）和3组（AMI联合环孢素治疗组）。结扎左前降支（LAD）诱发AMI。结扎15分钟后，第2组和第3组分别在结扎后LAD内注射生理盐水和环孢素（2.5 mg）。术后第14天进行超声心动图检查，然后进行动物祭祀。2组梗死面积（IA）明显大于3组(p
Background: We tested whether intra-coronary administration of cyclosporine effectively preserves left ventricular (LV) function in porcine acute anterior wall infarction (AMI).Methods and results: Eighteen male mini-pigs were randomized into groups 1 (control), 2 (AMI alone), and 3 (AMI with cyclosporine treatment). AMI was induced by ligating middle left anterior descending artery (LAD). Fifteen minutes after ligation, saline and cyclosporine (2.5 mg) combination was injected into LAD beyond ligation in groups 2 and 3, respectively. Echocardiography was performed after 14 days, followed by animal sacrifice. Larger infarcted area (IA) was noted in group 2 than in group 3 (p