Hormonal influences on lung function and response to environmental agents: lessons from animal models of respiratory disease.
Hormonal influences on lung function and response to environmental agents: lessons from animal models of respiratory disease.
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DOI：
10.1513/pats.200904-020rm
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发表时间：
2009-12-01
期刊：
影响因子：
--
通讯作者：
Zeldin, Darryl C
中科院分区：
文献类型：
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作者：
Card, Jeffrey W;Zeldin, Darryl C
在人类和实验动物中进行的大量研究发现，呼吸生理学和肺对环境因子的反应存在相当大的性别差异。这些差异似乎至少部分是由性激素及其核受体介导的。此外，动物模型越来越多地用于研究各种人类肺部疾病的致病机制和测试潜在的治疗方法，其中许多似乎受到性和性激素的影响。在这篇文章中，数据总结了肺功能和疾病的研究中，已观察到的性别差异。特别关注急性肺损伤、非过敏性和过敏性肺部炎症和肺纤维化的动物模型。预计在动物模型中继续研究性和性激素的作用将为各种急性和慢性人类肺部疾病的发病机制和潜在治疗提供有价值的见解。
Numerous studies in humans and experimental animals have identified considerable sex differences in respiratory physiology and in the response of the lung to environmental agents. These differences appear to be mediated, at least in part, by sex hormones and their nuclear receptors. Moreover, animal models are increasingly used to study pathogenic mechanisms and test potential therapies for a variety of human lung diseases, many of which appear to be influenced by sex and sex hormones. In this article, data are summarized from studies of lung function and disease in which sex differences have been observed. Specific attention is paid to animal models of acute lung injury, nonallergic and allergic lung inflammation, and lung fibrosis. It is anticipated that continued investigation of the role of sex and sex hormones in animal models will provide valuable insight into the pathogenesis and potential treatments for a variety of acute and chronic human lung diseases.