Resting-State Networks Associated with Behavioral and Self-Reported Measures of Persecutory Ideation in Psychosis.
Resting-State Networks Associated with Behavioral and Self-Reported Measures of Persecutory Ideation in Psychosis.
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DOI：
10.3390/brainsci11111490
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发表时间：
2021-11-11
期刊：
影响因子：
3.3
通讯作者：
MacDonald AW 3rd
中科院分区：
文献类型：
--
作者：
Yu L;Kazinka R;Pratt D;Kwashie A;MacDonald AW 3rd
持续性思维是一种自我指涉的错觉，尽管缺乏证据，但它仍然是恶意的目标。维斯纳等人（2021）发现，在执行经济社会决策任务的精神病患者中，左额顶叶（lFP）网络和眶额皮质（OFC）部分之间的连接性降低与迫害行为增加相关，该任务可以衡量对伴侣恶意行为的预期。如果这种模式可以在静息状态下观察到，这将表明一个功能结构的前易感个体迫害的想法。44例精神障碍早期患者提供了9个脑网络（包括FP网络和类似的OFC区域）的静息态功能连接磁共振成像数据。正如预测的那样，我们发现了一个显着的负相关关系lFP-OFC在休息和水平的可疑的不信任的决策任务，使用组内相关设计。此外，自我报告的迫害意念与右额顶（RFP）网络和眶额皮层之间的连接显着相关。我们将先前的研究结果扩展到静息状态下精神病患者的lFP网络和OFC之间的连接减少，并观察到可能的半球差异，例如更大的rFP-OFC连接预测自我报告的迫害意念升高，这表明lFP和rFP在迫害社会互动中的作用之间存在潜在差异。
Persecutory ideations are self-referential delusions of being the target of malevolence despite a lack of evidence. Wisner et al. (2021) found that reduced connectivity between the left frontoparietal (lFP) network and parts of the orbitofrontal cortex (OFC) correlated with increased persecutory behaviors among psychotic patients performing in an economic social decision-making task that can measure the anticipation of a partner’s spiteful behavior. If this pattern could be observed in the resting state, it would suggest a functional-structural prior predisposing individuals to persecutory ideation. Forty-four patients in the early course of a psychotic disorder provided data for resting-state functional connectivity magnetic resonance imaging across nine brain networks that included the FP network and a similar OFC region. As predicted, we found a significant and negative correlation between the lFP–OFC at rest and the level of suspicious mistrust on the decision-making task using a within-group correlational design. Additionally, self-reported persecutory ideation correlated significantly with the connectivity between the right frontoparietal (rFP) network and the OFC. We extended the previous finding of reduced connectivity between the lFP network and the OFC in psychosis patients to the resting state, and observed a possible hemispheric difference, such that greater rFP–OFC connectivity predicted elevated self-reported persecutory ideation, suggesting potential differences between the lFP and rFP roles in persecutory social interactions.
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DOI：
10.1017/s1355617711001688
发表时间：
2012-03
影响因子：
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DOI：
10.1073/pnas.0308627101
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