Chronic Japanese schistosomiasis and hepatocellular carcinoma: ten years of follow-up in Yamanashi Prefecture, Japan.
Chronic Japanese schistosomiasis and hepatocellular carcinoma: ten years of follow-up in Yamanashi Prefecture, Japan.
复制标题
慢性日本血吸虫病和肝细胞癌：日本山梨县十年随访。
DOI：
--
复制
发表时间：
1999
影响因子：
11.1
通讯作者：
Y. Matsumoto
中科院分区：
文献类型：
--
作者：
Fumiyoshi Iida;R. Iida;H. Kamijo;K. Takaso;Yoshiki Miyazaki;W. Funabashi;Kazuko Tsuchiya;Y. Matsumoto
在研究区开展的初步研究中，我们发现19.1%(173/907)的慢性肝病患者和51%(35/68)的肝细胞癌患者感染了日本血吸虫病。对571例身体解剖数据的分析显示，在肝癌和其他肝病病例中，血吸虫病的发病率也同样高。10多年来的前瞻性病例对照研究表明，慢性血吸虫病患者中发生肝癌的比例为5.4%(26/484)，慢性肝病(肝炎、肝硬变等)患者中发生肝癌的比例为7.5%(23/307)。差异无统计学意义(P=0.228)。丙型肝炎抗体阳性率在血吸虫病组(36.5%，95%CI=44.9-28.1%)和慢性肝病组(56.0%)中较高，慢性肝炎占39%(P=0.028)。对可能导致肝癌和血吸虫病发展的各种因素进行了调查，但没有发现血吸虫病与肝癌有显著相关性的证据。HCVAb的高发病率被认为是慢性血吸虫病患者发生肝细胞癌的原因之一。在这项研究中纳入了HCVAb的检测后，尚未证实乙肝病毒感染在血吸虫病患者肝癌发生中的作用。
In a preliminary study carried out in the study area we found that 19.1% (173/907) of patients with chronic liver disease and 51% (35/68) of hepatocellular carcinoma cases were infected with Japanese schistosomiasis. Analysis of data from 571 autopsies revealed a similarly high incidence of schistosomiasis among cases of hepatoma and other liver diseases. A prospective case-control study conducted over 10 years showed that hepatoma developed in 5.4% (26/484) of chronic schistosomiasis cases and in 7.5% (23/307) of patients with chronic liver disease (hepatitis, cirrhosis, etc). The difference was not statistically significant (P = 0.228). A high incidence of hepatitis C virus (HCV) antibody (HCVAb) was found in the schistosomiasis group (36.5%; 95% CI = 44.9-28.1%) and in the chronic liver disease group (56.0%), 39% of whom had chronic hepatitis (P = 0.028). Various factors that might have contributed to the development of hepatoma and schistosomiasis were investigated, but no evidence of a significant correlation between schistosomiasis and hepatoma was found. The high incidence of HCVAb was considered to have been responsible for the development of hepatocellular carcinoma in chronic schistosomiasis patients. The role of HBV infection in the development of hepatoma in schistosomiasis patients was not confirmed after an assay for HCVAb was included in the study.