A common neural scale for the subjective pleasantness of different primary rewards
A common neural scale for the subjective pleasantness of different primary rewards
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DOI：
10.1016/j.neuroimage.2010.03.043
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发表时间：
2010-07-01
期刊：
影响因子：
5.7
通讯作者：
Passingham, Richard E.
中科院分区：
文献类型：
--
作者：
Grabenhorst, Fabian;D'Souza, Arun A.;Passingham, Richard E.
当做出经济决策时，它是在不同价值观的目标之间进行的，而且价值观必须处于同一尺度。在这里，我们使用功能性 MRI 来寻找一个大脑区域，该区域代表同一神经尺度上两种不同奖励的主观愉悦感。我们发现腹侧前额叶皮层的活动与两种根本不同的奖励（嘴里的味道和手上的温暖）的主观愉悦感相关。证据来自两项不同的调查、两项独立功能磁共振成像研究的组间比较以及一项受试者内研究。在后者中，我们发现腹侧前额叶皮层相同体素的神经活动与不同奖励的主观愉悦感相关。此外，对于不同的奖励，描述激活和主观愉悦感之间关系的回归线的斜率和截距高度相似。我们还提供证据表明激活不仅仅代表多感官整合或奖励的显着性。研究结果表明，人脑中存在一个特定区域，其中神经活动与不同质的主要奖励的主观愉悦程度成正比。这表明大脑处理的原则对于奖励评估和决策非常重要。 (C) 2010 Elsevier Inc. 保留所有权利。
When an economic decision is taken, it is between goals with different values, and the values must be on the same scale. Here, we used functional MRI to search for a brain region that represents the subjective pleasantness of two different rewards on the same neural scale. We found activity in the ventral prefrontal cortex that correlated with the subjective pleasantness of two fundamentally different rewards, taste in the mouth and warmth on the hand. The evidence came from two different investigations, a between-group comparison of two independent fMRI studies, and from a within-subject study. In the latter, we showed that neural activity in the same voxels in the ventral prefrontal cortex correlated with the subjective pleasantness of the different rewards. Moreover, the slope and intercept for the regression lines describing the relationship between activations and subjective pleasantness were highly similar for the different rewards. We also provide evidence that the activations did not simply represent multisensory integration or the salience of the rewards. The findings demonstrate the existence of a specific region in the human brain where neural activity scales with the subjective pleasantness of qualitatively different primary rewards. This suggests a principle of brain processing of importance in reward valuation and decision-making. (C) 2010 Elsevier Inc. All rights reserved.