The genome of Aiptasia, a sea anemone model for coral symbiosis
The genome of Aiptasia, a sea anemone model for coral symbiosis
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Aiptasia 的基因组，一种珊瑚共生的海葵模型
DOI：
10.1073/pnas.1513318112
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发表时间：
2015-09-22
影响因子：
11.1
通讯作者：
Voolstra, Christian R.
中科院分区：
文献类型：
--
作者：
Baumgarten, Sebastian;Simakov, Oleg;Voolstra, Christian R.
最多样化的海洋生态系统--珊瑚礁--依赖于刺胞动物宿主（珊瑚）和细胞内光合甲藻之间的功能性共生。这种内共生现象的分子和细胞机制还没有得到很好的理解，部分原因是珊瑚实验工作的困难。小海葵Aiptasia为研究这些机制提供了一个易于处理的实验室模型。在这里，我们报告Aiptasia基因组的组装和分析，这将为未来的研究提供基础，并揭示了几个功能，可能是理解内共生的进化和功能的关键。这些功能包括基因组重排和分类学限制的基因，可能是功能相关的共生，宿主依赖藻类来源的营养素方面，一个新的和扩大的刺胞动物的特定家庭的模式识别受体，可能参与动物-藻类的相互作用，和广泛的谱系特异性水平基因转移。原核生物起源的基因的广泛整合，包括抗菌肽基因，大概反映了动物-藻类对也与其原核微生物组的密切关联。
The most diverse marine ecosystems, coral reefs, depend upon a functional symbiosis between a cnidarian animal host (the coral) and intracellular photosynthetic dinoflagellate algae. The molecular and cellular mechanisms underlying this endosymbiosis are not well understood, in part because of the difficulties of experimental work with corals. The small sea anemone Aiptasia provides a tractable laboratory model for investigating these mechanisms. Here we report on the assembly and analysis of the Aiptasia genome, which will provide a foundation for future studies and has revealed several features that may be key to understanding the evolution and function of the endosymbiosis. These features include genomic rearrangements and taxonomically restricted genes that may be functionally related to the symbiosis, aspects of host dependence on alga-derived nutrients, a novel and expanded cnidarian-specific family of putative pattern-recognition receptors that might be involved in the animal-algal interactions, and extensive lineage-specific horizontal gene transfer. Extensive integration of genes of prokaryotic origin, including genes for antimicrobial peptides, presumably reflects an intimate association of the animal-algal pair also with its prokaryotic microbiome.