A noninvasive method for monitoring respiratory rate of rats based on a microcantilever resonant humidity sensor
A noninvasive method for monitoring respiratory rate of rats based on a microcantilever resonant humidity sensor
复制标题
基于微悬臂梁谐振湿度传感器的大鼠呼吸频率无创监测方法
DOI：
10.1088/1361-6439/ab43e8
复制
发表时间：
2019-12-01
影响因子：
2.3
通讯作者：
Xie, Jin
中科院分区：
文献类型：
--
作者：
Guan, Yangyang;Le, Xianhao;Xie, Jin
在实验啮齿动物研究中，呼吸频率是一个重要的生理信号。提出了一种基于谐振式湿度传感器的无创监测大鼠呼吸频率的方法。该传感器由覆有氧化石墨烯(GO)薄膜的氮化铝(AlN)谐振微悬臂梁组成。该传感器具有较高的灵敏度和良好的重复性。通过将传感器与控制电路相结合，实现了快速响应的闭环呼吸测量系统。该系统通过检测呼气和吸气的相对湿度差，可以实时监测大鼠的呼吸频率。该方法具有响应快、体积小、成本低等优点。此外，通过将传感器与面罩集成，可以非侵入性地监测大鼠的呼吸频率。
Respiratory rate is a vital physiological signal in laboratory rodents research. This paper presents a noninvasive method based on resonant humidity sensor for monitoring respiratory rate of rats. The sensor is composed of an aluminum nitride (AlN) resonant microcantilever coated with graphene oxide (GO) film. The sensor shows high sensitivity and good repeatability. By combining the sensor with a control circuit, a closed-loop respiration measurement system is realized for fast response. The system can monitor respiratory rate of rats in real time by detecting relative humidity difference between exhaled and inhaled breath. The method has advantages of fast response, small size and low cost. Furthermore, the respiratory rate of rats can be noninvasively monitored by integrating the sensor with a face mask.