Diurnal variation of plasma cortisol and homovanillic acid in healthy subjects
Diurnal variation of plasma cortisol and homovanillic acid in healthy subjects
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DOI：
10.1016/0306-4530(95)00033-x
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发表时间：
1996-01-01
影响因子：
3.7
通讯作者：
Schatzberg, AF
中科院分区：
文献类型：
--
作者：
Posener, JA;Schildkraut, JJ;Schatzberg, AF
我们研究了健康人血浆皮质醇、多巴胺代谢物同质香草酸（HVA）和去甲肾上腺素水平之间的关系。血浆皮质醇和HVA水平在0800h测量，并在1300至1600h之间每15分钟采样一次。0800和1300h测定血浆去甲肾上腺素。皮质醇、HVA和去甲肾上腺素指数之间无显著相关。皮质醇和HVA都随着时间的推移而显著下降。纵向随机效应（LRE）模型用于检验个体皮质醇和HVA曲线是否随时间相关；此程序未发现显著相关。虽然抑郁症患者的皮质醇和儿茶酚胺指数之间存在显著相关性，但我们的研究结果并未表明健康受试者存在这种相关性。
We investigated the relationship between plasma levels of cortisol, the dopamine metabolite homovanillic acid (HVA) and norepinephrine in healthy human subjects. Plasma cortisol and HVA levels were measured at 0800h, and in an integrated sampling procedure involving samples every 15 min between 1300 and 1600h. Plasma norepinephrine was measured at 0800 and 1300h. Cortisol, HVA and norepinephrine indices did not show significant correlations with each other. Both cortisol and HVA showed significant decreases over time. Longitudinal Random Effects (LRE) models were used to test whether individual cortisol and HVA curves over time were correlated; significant corelations were not found with this procedure. While significant correlations between cortisol and catecholamine indices have been reported in depressed patients, our results do not suggest such correlations in healthy subjects.