Quantitative measures of cluster quality for use in extracellular recordings
Quantitative measures of cluster quality for use in extracellular recordings
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DOI：
10.1016/j.neuroscience.2004.09.066
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发表时间：
2005-01-01
期刊：
影响因子：
3.3
通讯作者：
Redish, AD
中科院分区：
文献类型：
--
作者：
Schmitzer-Torbert, N;Jackson, J;Redish, AD
虽然使用多通道电极（立体电极和四极电极）可以同时记录和识别许多神经元，但缺乏对这些记录中神经元质量的定量测量。在多通道记录中，每个尖峰波形在高维空间中被区分，使得传统的单位质量度量不适用。我们描述了单元隔离质量的两个度量，l比和隔离距离，并使用模拟和四极体记录来评估它们的性能。两种测量方法都量化了在同一多通道电极上同时记录的一个簇（假定的神经元）的峰值与其他峰值的分离程度。在模拟和四极体记录中，L-ratio和隔离距离可以区分分离良好和分离不良的簇。在同时记录细胞内和细胞外神经元的啮齿动物海马数据集中，隔离距离和L-ratio的值与正确识别尖峰有关。(c) 2005年。Elsevier Ltd.出版。版权所有。
While the use of multi-channel electrodes (stereotrodes and tetrodes) has allowed for the simultaneous recording and identification of many neurons, quantitative measures of the quality of neurons in such recordings are lacking. In multi-channel recordings, each spike waveform is discriminated in a high-dimensional space, making traditional measures of unit quality inapplicable. We describe two measures of unit isolation quality, L-ratio and Isolation Distance, and evaluate their performance using simulations and tetrode recordings. Both measures quantified how well separated the spikes of one cluster (putative neuron) were from other spikes recorded simultaneously on the same multichannel electrode. In simulations and tetrode recordings, both L-ratio and Isolation Distance discriminated well- and poorly-separated clusters. In data sets from the rodent hippocampus in which neurons were simultaneously recorded intracellularly and extracellularly, values of Isolation Distance and L-ratio were related to the correct identification of spikes. (C) 2005 IBRO. Published by Elsevier Ltd. All rights reserved.