Cancer after kidney transplantation in the United States
Cancer after kidney transplantation in the United States
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DOI：
10.1111/j.1600-6143.2004.00450.x
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发表时间：
2004-06-01
影响因子：
8.8
通讯作者：
Wang, CC
中科院分区：
文献类型：
--
作者：
Kasiske, BL;Snyder, JJ;Wang, CC
在单中心研究中，少量患者限制了肾脏移植后癌症的先前报道，并且在大型注册表中的病例不完整。 （n = 35765）使用Medicare账单索赔。对于大多数常见的肿瘤，e。 g。结肠，肺，前列腺，胃，食道，胰腺，卵巢和乳腺癌，肾脏移植后的癌症发生率与一般人群相比高约双重。黑色素瘤，白血病，肝胆肿瘤，宫颈和外阴阴道肿瘤每个都更为常见。睾丸和膀胱癌的增加了大约三倍，而肾癌大约有15倍。 Kaposi的肉瘤，非Hogkin的淋巴瘤和非黑色素瘤皮肤癌的增长了20倍以上。与等待名单上的患者相比，移植后几个肿瘤更为常见（P
Previous reports of cancer after kidney transplantation have been limited by small numbers of patients in single-center studies and incomplete ascertainment of cases in large registries.We examined rates of malignancies among first-time recipients of deceased or living donor kidney transplantations in 1995-2001 (n=35765) using Medicare billing claims.For most common tumors, e. g. colon, lung, prostate, stomach, esophagus, pancreas, ovary and breast, cancer rates were roughly twofold higher after kidney transplantation compared with the general population. Melanoma, leukemia, hepatobiliary tumors, cervical and vulvovaginal tumors were each approximately fivefold more common. Testicular and bladder cancers were increased approximately threefold, while kidney cancer was approximately 15-fold more common. Kaposi's sarcoma, non-Hogkin's lymphomas, and nonmelanoma skin cancers were more than 20-fold increased than in the general population. Compared with patients on the waiting list, several tumors were more common after transplantation (p