Dual Photoredox/Nickel-Catalyzed Regioselective Cross-Coupling of 2-Arylaziridines and Potassium Benzyltrifluoroborates: Synthesis of β-Substitued Amines
Dual Photoredox/Nickel-Catalyzed Regioselective Cross-Coupling of 2-Arylaziridines and Potassium Benzyltrifluoroborates: Synthesis of β-Substitued Amines
复制标题
2-芳基氮丙啶和三氟硼酸钾钾的双光氧化还原/镍催化区域选择性交叉偶联：β-取代胺的合成
DOI：
10.1021/acs.orglett.7b03747
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发表时间：
2018
期刊：
影响因子：
5.2
通讯作者：
Wen-Jing Xiao
中科院分区：
文献类型：
--
作者：
Xiao-Ye Yu;Quan-Quan Zhou;Peng-Zi Wang;Chun-Miao Liao;Jia-Rong Chen;Wen-Jing Xiao
首次报道了2-芳基氮杂环丙烷与苄基三氟硼酸钾的可见光光氧化还原和镍催化交叉偶联反应。该策略具有高官能团耐受性，在更受阻的C-N键处反应的排他性区域选择性，易于获得的底物和温和的氧化还原中性反应条件。以通常良好的产率获得各种二氨基取代的β-取代的胺。
A dual visible light photoredox and nickel-catalyzed cross-coupling reaction of 2-arylaziridines and potassium benzyltrifluoroborates is described for the first time. This strategy features high functional group tolerance, exclusive regioselectivity for reaction at the more hindered C–N bond, easily accessible substrates, and mild redox-neutral reaction conditions. A variety of diversely substituted β-substituted amines are obtained in generally good yields.