Macrophage migration inhibitory factor (MIF) in the stratum corneum: a marker of the local severity of atopic dermatitis
Macrophage migration inhibitory factor (MIF) in the stratum corneum: a marker of the local severity of atopic dermatitis
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DOI：
10.1111/exd.12520
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发表时间：
2014-10-01
影响因子：
3.6
通讯作者：
Shimizu, Tadamichi
中科院分区：
文献类型：
--
作者：
Yasuda, Chie;Enomoto, Akiko;Shimizu, Tadamichi
不同的生物标志物被用来评估特应性皮炎（AD）的严重程度；然而，确定局部皮肤病变的严重程度仍然很困难。MIF在皮肤炎症的病理生理中起着重要作用。为了确定角质层（SC）中的MIF水平是否可以作为AD病变严重程度的标志，我们检测了AD患者角质层中的MIF （scMIF）水平。采用胶带剥离法采集颊部、颈部和上臂皮肤SC，并测量scMIF水平。因此，在同一患者中，受累皮肤病变中的scMIF水平明显高于未受累区域。此外，scMIF水平与局部皮肤病变的严重程度显著相关。这些发现表明，scMIF水平可以作为评估AD局部严重程度的有效标志物。
Different biomarkers are used to evaluate the severity of atopic dermatitis (AD); however, it remains difficult to determine the severity of localized skin lesions. MIF plays an essential role in the pathophysiology of skin inflammation. To establish whether the MIF level in the stratum corneum (SC) serves as a marker of the severity of AD lesions, we examined the SC MIF (scMIF) levels in AD patients. The SC of the cheek, neck and upper arm skin was collected using tape stripping, and the scMIF levels were measured. Consequently, the scMIF levels were found to be significantly higher in the involved skin lesions than the uninvolved areas within the same patient. Moreover, the scMIF levels were significantly correlated with the severity of local skin lesions. These findings suggest that the scMIF level can be used as an effective marker for evaluating the local severity of AD.