NPCARE: database of natural products and fractional extracts for cancer regulation.
NPCARE: database of natural products and fractional extracts for cancer regulation.
复制标题
NPCARE：天然产物数据库和癌症调节的分数提取物。
DOI：
10.1186/s13321-016-0188-5
复制
发表时间：
2017
影响因子：
8.6
通讯作者：
Park H
中科院分区：
文献类型：
--
作者：
Choi H;Cho SY;Pak HJ;Kim Y;Choi JY;Lee YJ;Gong BH;Kang YS;Han T;Choi G;Cho Y;Lee S;Ryoo D;Park H
天然产物因其结构新奇、生物利用度高而成为开发抗肿瘤药物的重要资源。这就需要一个全面的数据库的天然产物和分级提取物的抗癌活性已得到验证。NPCARE（http：//silver.sejong.ac.kr/npcare）是一个可公开访问的在线数据库，其中包含用于癌症监管的天然产品和部分提取物。在NPCARE，人们可以探索从1952种不同的生物物种中分离出的6578种天然化合物和2566种部分提取物，包括植物，海洋生物，真菌和细菌，其抗癌活性已被1107种细胞系验证用于34种癌症类型。NPCARE中的每个条目都注释了癌症类型、生物资源的属和种名称、用于证明抗癌活性的细胞系、PubChem ID以及关于靶基因或蛋白质的大量信息。除了增加植物条目多达743属和197科，NPCARE还进一步丰富了各种非传统生物资源的天然产物和馏分提取物。NPCARE预计将成为发现新抗癌药物的主要途径，因为它包含了大量的分级提取物以及从各种生物资源中分离的天然化合物。本文的在线版本（doi：10.1186/s13321-016-0188-5）包含补充材料，可供授权用户使用。
Natural products have increasingly attracted much attention as a valuable resource for the development of anticancer medicines due to the structural novelty and good bioavailability. This necessitates a comprehensive database for the natural products and the fractional extracts whose anticancer activities have been verified. NPCARE (http://silver.sejong.ac.kr/npcare) is a publicly accessible online database of natural products and fractional extracts for cancer regulation. At NPCARE, one can explore 6578 natural compounds and 2566 fractional extracts isolated from 1952 distinct biological species including plants, marine organisms, fungi, and bacteria whose anticancer activities were validated with 1107 cell lines for 34 cancer types. Each entry in NPCARE is annotated with the cancer type, genus and species names of the biological resource, the cell line used for demonstrating the anticancer activity, PubChem ID, and a wealth of information about the target gene or protein. Besides the augmentation of plant entries up to 743 genus and 197 families, NPCARE is further enriched with the natural products and the fractional extracts of diverse non-traditional biological resources. NPCARE is anticipated to serve as a dominant gateway for the discovery of new anticancer medicines due to the inclusion of a large number of the fractional extracts as well as the natural compounds isolated from a variety of biological resources. The online version of this article (doi:10.1186/s13321-016-0188-5) contains supplementary material, which is available to authorized users.