Characterization of murine leukemia virus restriction in mammals
Characterization of murine leukemia virus restriction in mammals
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DOI：
10.1128/jvi.77.24.13403-13406.2003
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发表时间：
2003-12-01
影响因子：
5.4
通讯作者：
Towers, GJ
中科院分区：
文献类型：
--
作者：
Besnier, C;Ylinen, L;Towers, GJ
在一系列哺乳动物的细胞中检查了鼠白血病病毒（MLV）的限制性。所有非鼠限制是N-嗜性MLV感染的可饱和阻断，有几个是在逆转录之前。我们证明了蝙蝠细胞中的限制，并表明，如果我们在人类细胞中表达鼠限制因子Fv 1，那么Fv 1，而不是人类宿主，定义了感染被阻断的阶段。
Restriction of murine leukemia virus (MLV) was examined in cells from a range of mammals. All nonmurine restrictions were saturable blocks to N-tropic MLV infection, and several were prior to reverse transcription. We demonstrate restriction in cells from bat and show that if we express the murine restriction factor Fv1 in human cells, then Fv1, not the human host, defines the stage at which infection is blocked.