Brain metabolic changes during cigarette craving
Brain metabolic changes during cigarette craving
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DOI：
10.1001/archpsyc.59.12.1162
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发表时间：
2002-12-01
影响因子：
--
通讯作者：
Jarvik, ME
中科院分区：
文献类型：
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作者：
Brody, AL;Mandelkern, MA;Jarvik, ME
背景：在功能性脑成像研究中，成瘾个体接触与可卡因、阿片类药物和酒精相关的线索与前扣带回 gyrus、杏仁核、眶额皮质和背外侧前额叶皮质的激活有关。对这些物质的渴望与眶额皮质、背外侧前额叶皮质和前脑岛的活动呈正相关。本研究的目的是确定重度吸烟者在接触与香烟相关的线索时局部脑葡萄糖代谢的变化以及渴望与局部代谢之间的相关性。
方法：20名重度吸烟者（每天吸烟≥20支）和20名非吸烟对照受试者以随机顺序相隔10天接受2次氟 - 18 - 氟脱氧葡萄糖正电子发射断层扫描：一次是在观看呈现与香烟相关线索的录像带并手持香烟时，另一次是在观看教育（自然）录像带并手持中性物体（笔）时。
结果：从中性扫描到香烟线索扫描，重度吸烟者在跨越中线的膝下前扣带回相对葡萄糖代谢的增加幅度大于非吸烟对照组。在双侧眶额皮质、背外侧前额叶皮质和前脑岛，渴望强度与代谢之间发现显著正相关。在渴望与右侧感觉运动皮质的代谢之间发现了意外的正相关。
结论：在接触与香烟相关的线索和对香烟产生渴望期间，与唤醒、强迫性重复行为、感觉整合和情景记忆相关的脑区被激活。这些局部脑激活以及与渴望的关联与其他成瘾物质的研究结果相似。
Background: In functional brain imaging studies, exposure to cues related to cocaine, opiates, and alcohol in dependent individuals is associated with activation of the anterior cingulate gyrus, amygdala, orbitofrontal cortex, and dorsolateral prefrontal cortex. Craving for these substances positively correlates with activity in the orbitofrontal cortex, dorsolateral prefrontal cortex, and anterior insula. The objective of this study was to determine changes in regional cerebral glucose metabolism and correlations between craving and regional metabolism in heavy cigarette smokers exposed to cigarette-related cues.Methods: Twenty heavy smokers (who smoked greater than or equal to20 cigarettes per day) and 20 nonsmoking control subjects underwent 2 fluorine 18-fluorodeoxyglucose positron emission tomography scans 10 days apart in randomized order: one while watching a videotape that presented cigarette-related cues and handling a cigarette, and the other while watching an educational (nature) videotape and handling a neutral object (pen).Results: From the neutral to the cigarette cue scan, heavy smokers had greater increases than nonsmoking controls in relative glucose metabolism in the perigenual anterior cingulate gyrus spanning the midline. Significant positive correlations were found between intensity of craving and metabolism in the orbitofrontal cortex, dorsolateral prefrontal cortex, and anterior insula bilaterally. An unexpected positive association was found between craving and metabolism in the right sensorimotor cortex.Conclusions: Brain regions associated with arousal, compulsive repetitive behaviors, sensory integration, and episodic memory are activated during exposure to cigarette-related cues and cigarette craving. These regional brain activations and associations with craving are similar to findings with other addictive substances.