THE EARLY EFFECTS OF METHYLMERCURY ON THE DEVELOPING RAT-BRAIN
THE EARLY EFFECTS OF METHYLMERCURY ON THE DEVELOPING RAT-BRAIN
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DOI：
10.1007/bf00307699
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发表时间：
1990-01-01
影响因子：
12.7
通讯作者：
VERHOEF, A
中科院分区：
文献类型：
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作者：
GEELEN, JAG;DORMANS, JAMA;VERHOEF, A
有机汞化合物对大脑发育的影响是众所周知的，因为人们在水俣湾地区和伊拉克大规模接触甲基汞。对产前接触过的儿童进行的大脑神经病理学检查显示，大脑和小脑皮质发育不良、神经元异位和其他几种发育障碍。在这项实验研究中，我们研究了甲基汞引起的大脑异常的发育机制。通过检查治疗后不久的胎儿，我们集中在治疗的最初效果。妊娠大鼠在第18天腹腔注射10 mg/kg氯化甲基汞。给药后2 h，脑毛细血管内皮细胞已发生线粒体变性。随后，发育障碍干扰了脑室区的细胞排列，干扰了中间区的神经元迁移，并干扰了皮质细胞结构的发育。出血区出现巨噬细胞和空洞。有人建议，在实验中看到的异常可以被认为是最初的甲基汞诱导的影响，与其他各种毒性效应相结合，最终导致异常已被观察到在产前接触甲基汞的儿童的大脑。
The effects of organic mercury compounds on the development of the brain are well known since the exposure of people at a large scale to methylmercury in the Minamata Bay area and in Iraq. The neuropathological examination of the brains of children prenatally exposed revealed dysplasia of the cerebral and cerebellar cortex, neuronal ectopia and several other developmental disturbances. In this experimental study we examined developmental mechanisms involved in methylmercury-induced cerebral anomalies. By examining the fetuses soon after treatment we concentrated in the initial effects of the treatment. The pregnant rats were given 10 mg/kg methylmercury chloride i.p. on day 18. Already at 2 h after administration mitochondrial degeneration occurred in the endothelium of the cerebral capillaries. Subsequently hemorrhages developed interfering with the cellular arrangement in the ventricular zone, with neuronal migration in the intermediate zone and with the development of the cortical cytoarchitecture. Macrophages and cavities appeared in the hemorrhagic areas. It is suggested that the abnormalities seen in the experiments can be considered as the initial methylmercury-induced effects which in combination with various other toxic effects, ultimately result in the anomalies that have been observed in the brains of children prenatally exposed to methylmercury.