Significance of micrometastasis in bone marrow and blood of operable breast cancer patients: research tool or clinical application?
Significance of micrometastasis in bone marrow and blood of operable breast cancer patients: research tool or clinical application?
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DOI：
10.1586/14737140.7.10.1463
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发表时间：
2007-10
影响因子：
3.3
通讯作者：
J. Lang;C. Hall;Balraj Singh;A. Lucci
中科院分区：
文献类型：
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作者：
J. Lang;C. Hall;Balraj Singh;A. Lucci
大约25%的无淋巴结转移的乳腺癌患者发生全身复发。越来越多的数据支持这一观点，即乳腺癌细胞的血行播散独立于疾病的淋巴扩散;然而，目前的临床实践并不涉及循环或播散细胞的常规分析。最近的研究表明，血液中的循环肿瘤细胞（CTC）和骨髓中的播散性肿瘤细胞（DTC）都可以使用多种技术进行鉴定。现在很清楚的是，DTC的存在与临床上明显的骨转移的后续发展相关，并且与乳腺癌的预后更差相关。虽然有数据表明CTC在转移性乳腺癌患者中的预后意义，但关于CTC在可手术患者中的数据很少。诸如癌症干细胞表型和/或某些微环境条件的存在等因素参与了原发性乳腺癌远处转移的建立，强调了在该领域进一步研究的必要性。本报告的目的是审查可手术乳腺癌患者中CTC和DTC的相关数据。
Approximately 25% of breast cancer patients without lymph node metastases develop systemic relapse. A growing body of data supports the notion that hematogenous dissemination of breast cancer cells occurs independently of lymphatic spread of disease; however, current clinical practice does not involve routine analysis of circulating or disseminated cells. Recent studies have documented that both circulating tumor cells (CTCs) within the blood and disseminated tumor cells (DTCs) in bone marrow can be identified using a variety of techniques. It is now clear that the presence of DTCs correlates with subsequent development of clinically evident bone metastases, and a worse outcome from breast cancer. While there are data identifying prognostic significance of CTCs in patients with metastatic breast cancer, there are few data regarding CTCs in operable patients. Factors such as presence of a cancer stem cell phenotype and/or certain microenvironmental conditions are involved in the establishment of distant metastases from a primary breast cancer, emphasizing the need for further studies within this area. The purpose of this report is to review the data regarding CTCs and DTCs in patients with operable breast cancer.