Three-dimensional visualization of choroidal vessels by using standard and ultra-high resolution scattering optical coherence angiography
Three-dimensional visualization of choroidal vessels by using standard and ultra-high resolution scattering optical coherence angiography
复制标题
DOI：
10.1364/oe.15.007538
复制
发表时间：
2007-06-11
期刊：
影响因子：
3.8
通讯作者：
Yasuno, Yoshiaki
中科院分区：
文献类型：
--
作者：
Hong, Youngjoo;Makita, Shuichi;Yasuno, Yoshiaki
散射光学相干血管造影（S-OCA）是一种基于高速标准800 nm波段谱域光学相干断层成像（SD-OCT）和超高分辨率SD-OCT（在组织中的轴向分辨率分别为6.1 μ m和2.9 μ m）的无创成像方法。在本文中，我们已经证明了使用这种方法在体内人类视网膜成像。通过分割脉络膜血管获得脉络膜脉管系统的三维视图;这是在相对于视网膜色素上皮的每个深度平面处使用基于强度阈值的二值化来完成的。血管投影图像通过整合分割的脉络膜血管系统获得。为了评估所提出的方法的可行性，我们比较了这些图像与使用现有的侵入性方法，如荧光素血管造影和吲哚菁绿色血管造影。应用S-OCA对年龄相关性黄斑变性和息肉状脉络膜血管病变进行检查，获得了临床满意的图像。(c)2007年，美国光学学会。
Scattering optical coherence angiography (S-OCA) is a non-invasive imaging method that is based on the high-speed standard 800nm band spectral-domain optical coherence tomography (SD-OCT) and the ultra-high-resolution SD-OCT which has the axial resolution of 6.1 mu m and 2.9 mu m in tissue, respectively. In this paper, we have demonstrated the use of this method for in vivo human retinal imaging. A three-dimensional view of the choroidal vasculature was obtained by segmenting the choroidal vessels; this was done using intensity threshold based binarization at each depth plane relative to the retinal pigment epithelium. A vascular projection image was obtained by integrating the segmented choroidal vasculature. In order to assess the feasibility of the proposed method, we compared these images with those obtained using existing invasive methods such as fluorescein angiography and indocyanine green angiography. Clinically worthful images are obtained from the application of S-OCA to the age-related macular degeneration and polypoidal choroidal vasculopathy. (c) 2007 Optical Society of America.