Predictors of Cancer Risk in the Long-Term Solid-Organ Transplant Recipient
Predictors of Cancer Risk in the Long-Term Solid-Organ Transplant Recipient
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DOI：
10.1097/01.tp.0000436907.56425.5c
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发表时间：
2014-03-27
期刊：
影响因子：
6.2
通讯作者：
Wood, Kathryn J.
中科院分区：
文献类型：
--
作者：
Sherston, Sam N.;Carroll, Robert P.;Wood, Kathryn J.
恶性肿瘤日益成为实体器官受者死亡的主要原因。移植人群的癌症发病率总体比普通人群高出三到五倍，且晚期疾病的预后较差。深入识别具有发生移植后恶性肿瘤特定风险的患者对于确保采取适当措施降低相关发病率和死亡率至关重要。本综述重点关注潜在的临床、免疫学和遗传转化标记，旨在识别患有癌症高风险的长期实体器官移植患者。
Malignancy is increasingly the leading cause of mortality in solid-organ recipients. Cancer incidence among the transplant population is overall threefold to fivefold higher than the general population with poorer outcomes for late-stage disease. Insights into the identification of patients at particular risk of developing a posttransplantation malignancy are imperative to ensure appropriate measures are instigated to reduce associated morbidity and mortality. This review focuses on potential clinical, immunologic, and genetic translational markers aimed at identifying long-term solid-organ transplant patients at high risk of developing cancer.