Meta-Analyses of the Effect of CYP1A1 and CYP2D6 Polymorphisms on the Risk of Head and Neck Squamous Cell Carcinoma
Meta-Analyses of the Effect of CYP1A1 and CYP2D6 Polymorphisms on the Risk of Head and Neck Squamous Cell Carcinoma
复制标题
DOI：
10.1159/000363428
复制
发表时间：
2014-08-01
影响因子：
2.4
通讯作者：
Zhang, Jing
中科院分区：
文献类型：
--
作者：
Han, Jiming;Wang, Lu;Zhang, Jing
背景：CYP 1A 1和CYP 2D 6是编码参与有毒化学物质和致癌物代谢的酶的重要基因。然而，CYP 1A 1和CYP 2D 6多态性与头颈部鳞状细胞癌（HNSCC）风险之间的相关性尚未得到结论性的报道。我们进行了一项荟萃分析，以评估CYP 1A 1和CYP 2D 6多态性与HNSCC风险的相关性。方法：数据库检索产生了19项相关研究。荟萃分析中纳入了3种多态性：CYP 1A 1、CYP 2D 6 *4和CYP 2D 6 *10。在分析中使用随机或固定效应模型。结果如下：CYP 1A 1多态性与HNSCC相关（m1 m1 vs. m1 m2：比值比（OR）= 1.26，95%置信区间（CI）= 1.030-1.542，p（异质性）= 0.025;隐性模型：OR = 1.316，95% CI = 1.065-1.625，p（异质性）= 0.001）。该分析显示了亚洲人群中CYP 2D 6 *4多态性与HNSCC之间相关的证据;然而，在其他模型中也观察到阴性结果。CYP 2D 6 *10基因多态性与HNSCC风险之间也存在显著相关性。结论：目前的研究表明，CYP 1A 1和CYP 2D 6多态性与HNSCC的发生和进展的易感性相关。
Background: CYP1A1 and CYP2D6 are important genes encoding enzymes involved in the metabolism of toxic chemicals and carcinogens. However, inconclusive results for the association between CYP1A1 and CYP2D6 polymorphisms and the risk of head and neck squamous cell carcinoma (HNSCC) have been reported. We conducted a meta-analysis to evaluate the association of CYP1A1 and CYP2D6 polymorphisms with the risk of HNSCC. Methods: A database search yielded 19 relevant studies. 3 polymorphisms were included in the meta-analysis: CYP1A1, CYP2D6*4 and CYP2D6*10. Random or fixed effect models were used in the analysis. Results: The CYP1A1 polymorphism was associated with HNSCC (for m1m1 vs. m1m2: odds ratio (OR) = 1.26, 95% confidence interval (CI) = 1.030-1.542, p(heterogeneity) = 0.025; for the recessive model: OR = 1.316, 95% CI = 1.065-1.625, p(heterogeneity) = 0.001). The analysis showed evidence for association between the CYP2D6*4 polymorphism and HNSCC in Asian populations; however, negative results were also observed in other models. A significant association was also observed between CYP2D6*10 polymorphism and HNSCC risk. Conclusions: The current study demonstrates that the CYP1A1 and CYP2D6 polymorphisms are associated with susceptibility to both development and progression of HNSCC.