Delay-induced degrade-and-fire oscillations in small genetic circuits.
Delay-induced degrade-and-fire oscillations in small genetic circuits.
复制标题
DOI：
10.1103/physrevlett.102.068105
复制
发表时间：
2009-02-13
影响因子：
8.6
通讯作者：
Tsimring LS
中科院分区：
文献类型：
--
作者：
Mather W;Bennett MR;Hasty J;Tsimring LS
最近在一个由耦合的正反馈和负反馈循环组成的合成基因网络中观察到了强大的振荡。降级和火力”的动态。激活和紧密的表达。当调节分子的数量较小时，振动性最小值在振荡性最小值附近的波动很大。
Robust oscillations have recently been observed in a synthetic gene network composed of coupled positive and negative feedback loops. Here we use deterministic and stochastic modeling to investigate how a small time delay in such regulatory networks can lead to strongly nonlinear oscillations that can be characterized by “degrade and fire” dynamics. We show that the period of the oscillations can be significantly greater than the delay time, provided the circuit components possess strong activation and tight repression. The variability of the period is strongly influenced by fluctuations near the oscillatory minima, when the number of regulatory molecules is small. We explore the effect of the positive feedback loop on the robustness of these oscillations.