Altered connectivity patterns among resting state networks in patients with ischemic white matter lesions
Altered connectivity patterns among resting state networks in patients with ischemic white matter lesions
复制标题
缺血性白质病变患者静息状态网络之间的连接模式改变
DOI：
10.1007/s11682-017-9793-9
复制
发表时间：
2018-10-01
影响因子：
3.2
通讯作者：
Thompson, Paul
中科院分区：
文献类型：
--
作者：
Ding, Ju-Rong;Ding, Xin;Thompson, Paul
白质病变（WMLs）与认知和运动能力下降有关。静息态网络（RSNs）是人脑中空间连贯的模式，它们之间的相互作用维持着我们的日常功能。因此，研究静息态网络之间改变的内部和网络间连接性可能有助于理解白质病变与认知和运动功能受损之间的关联。在此，我们基于6个明确界定的静息态网络——默认模式网络（DMN）、背侧注意网络（DAN）、额顶控制网络（FPCN）、听觉网络（AN）、感觉运动网络（SMN）和视觉网络（VN），评估了15例缺血性白质病变患者和15例对照者的功能连接模式的改变。在患者中，还对这些改变与认知测试分数（包括简易精神状态检查表（MMSE）和蒙特利尔认知评估（MoCA）分数）进行了斯皮尔曼相关分析。我们的结果显示，网络间连接性广泛改变，主要涉及SMN、DMN、FPCN和DAN，并且一些改变与患者的认知测试分数相关。SMN - AN、SMN - VN、FPCN - AN、DAN - VN这几对网络之间功能连接性降低可能是缺血性白质病变患者认知和运动能力下降的原因，而DMN - AN、DMN - FPCN和DAN - FPCN这几对网络之间功能连接性增加可能反映了白质受损后的功能网络重组。出乎意料的是，在AN和VN内部发现了网络内连接性的改变，这可能解释了与白质病变相关的语言流畅性和信息检索方面的障碍。这项研究强调了功能连接性在理解白质病变如何影响认知和行为功能障碍方面的重要性。
White matter lesions (WMLs) have been associated with cognitive and motor decline. Resting state networks (RSNs) are spatially coherent patterns in the human brain and their interactions sustain our daily function. Therefore, investigating the altered intra- and inter-network connectivity among the RSNs may help to understand the association of WMLs with impaired cognitive and motor function. Here, we assessed alterations in functional connectivity patterns based on six well-defined RSNs—the default mode network (DMN), dorsal attention network (DAN), frontal-parietal control network (FPCN), auditory network (AN), sensory motor network (SMN) and visual network (VN)—in 15 patients with ischemic WMLs and 15 controls. In the patients, Spearman’s correlation analysis was further performed between these alterations and cognitive test scores, including Mini-Mental State Examination (MMSE) and Montreal Cognitive Assessment (MoCA) scores. Our results showed wide alterations of inter-network connectivity mainly involving the SMN, DMN, FPCN and DAN, and some alterations correlated with cognitive test scores in the patients. The reduced functional connectivities in the SMN-AN, SMN-VN, FPCN-AN, DAN-VN pairs may account for the cognitive and motor decline in patients with ischemic WMLs, while the increased functional connectivities in the DMN-AN, DMN-FPCN and DAN-FPCN pairs may reflect a functional network reorganization after damage to white matter. It is unexpected that altered intra-network connectivities were found within the AN and VN, which may explain the impairments in verbal fluency and information retrieval associated with WMLs. This study highlights the importance of functional connectivity in understanding how WMLs influence cognitive and behavior dysfunction.