Liquid acrylate-endcapped biodegradable poly(epsilon-caprolactone-co-trimethylene carbonate). II. Computer-aided stereolithographic microarchitectural surface photoconstructs.
Liquid acrylate-endcapped biodegradable poly(epsilon-caprolactone-co-trimethylene carbonate). II. Computer-aided stereolithographic microarchitectural surface photoconstructs.
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液体丙烯酸酯封端的可生物降解聚（ε-己内酯-共-三亚甲基碳酸酯）。
DOI：
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发表时间：
2002
期刊：
影响因子：
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通讯作者：
M. Mizutani
中科院分区：
文献类型：
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作者：
T. Matsuda;M. Mizutani
先进的微型医疗设备可能需要计算机辅助光制造，通过这种方法，微结构表面设计和整个宏观形体设计是可行的。将使用三亚甲基二醇（TMG）或聚（乙二醇）（PEG）作为引发剂和用于随后封端的丙烯酸酯基团制备的液体丙烯酸酯封端的聚（ε-己内酯-co-三亚甲基碳酸酯）、聚（CL/TMC）用作可光固化共聚物。使用定制设计的装置制备立体光刻微结构的光构建体，所述装置具有由计算机辅助设计程序驱动的移动紫外（UV）光笔。所制备的光构建体包括微针、微柱和表面上的微库。在体外水解降解进行表面侵蚀时，采用疏水TMG基光固化共聚物，而非常快速的降解亲水PEG基光固化共聚物可能通过协同作用的表面侵蚀和本体降解观察。在大鼠皮下植入后的体内水解行为表明，基于TMG的光构建体的表面侵蚀进行。将抗炎药物（吲哚美辛）装载到微针结构表面中最大限度地减少了炎症反应。讨论了生物医学微结构在生物医学应用中的可能性.
Advanced micromedical devices may require computer-aided photofabrication, by which microarchitectural surface design and entire macroshaped body design are feasible. Liquid acrylate-endcapped poly(epsilon-caprolactone-co-trimethylene carbonate)s, poly(CL/TMC)s, prepared using trimethylene glycol (TMG) or poly(ethylene glycol) (PEG) as an initiator and an acrylate group for subsequent terminal capping, were used as photocurable copolymers. The stereolithographically microarchitectured photoconstructs were prepared using a custom-designed apparatus with a moving ultraviolet (UV) light pen driven by a computer-assisted design program. The prepared photoconstructs included microneedles, a microcylinder and microbanks on surfaces. In vitro hydrolytic degradation proceeded with surface erosion when hydrophobic TMG-based photocured copolymers were employed, whereas very fast degradation of hydrophilic PEG-based photocured copolymers probably via concerted actions of surface erosion and bulk degradation was observed. In vivo hydrolytic behavior upon subcutaneous implantation in rats indicated that surface erosion proceeded for TMG-based photoconstructs. Anti-inflammatory drug (indomethacin) loading into microneedle-structured surfaces minimized inflammatory reactions. The possible biomedical microarchitectural three dimensinal in biomedical application photoconstructs was discussed.