Natural History of Obesity Subphenotypes: Dynamic Changes Over Two Decades and Prognosis in the Framingham Heart Study
Natural History of Obesity Subphenotypes: Dynamic Changes Over Two Decades and Prognosis in the Framingham Heart Study
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DOI：
10.1210/jc.2018-01321
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发表时间：
2019-03-01
影响因子：
5.8
通讯作者：
Vasan, Ramachandran S.
中科院分区：
文献类型：
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作者：
Echouffo-Tcheugui, Justin B.;Short, Meghan, I;Vasan, Ramachandran S.
内容：肥胖亚表型的自然史尚未完全阐明。目的：研究肥胖亚表型的动态变化及其与结果的关系。设计、设置、参与者和测量：Fractional Offspring队列受试者（n = 4291），参加了第2周期（1979年至1983年）至第7周期（1998年至2001年）的检查，其中包括26，508名参与者观察。肥胖亚表型[代谢健康非肥胖（MHNO）、代谢健康肥胖（MHO）、代谢不健康非肥胖（MUNO）和代谢不健康肥胖（MUO）]是根据代谢健康（
Context: The natural histories of obesity subphenotypes are incompletely delineated.Objectives: To investigate dynamic changes in obesity subphenotypes and associations with outcomes.Design, Setting, Participants, and Measurements: Framingham Offspring Cohort participants (n = 4291) who attended the examination cycles 2 (1979 to 1983) to 7 (1998 to 2001), which included 26,508 participant observations. Obesity subphenotypes [metabolically healthy nonobese (MHNO), metabolically healthy obese (MHO), metabolically unhealthy nonobese (MUNO), and metabolically unhealthy obese (MUO)] were ascertained based on metabolic health (