Studies on human sexual development. V. Concentrations of testosterone, 17-hydroxyprogesterone and progesterone in human amniotic fluid throughout gestation.
Studies on human sexual development. V. Concentrations of testosterone, 17-hydroxyprogesterone and progesterone in human amniotic fluid throughout gestation.
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人类性发育的研究。
DOI：
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发表时间：
1977
影响因子：
5.8
通讯作者：
J. Winter
中科院分区：
文献类型：
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作者：
G. Warne;C. Faiman;F. Reyes;J. Winter
用放射免疫法测定了正常妊娠9~40周羊水标本中未结合睾酮、17-羟孕酮和孕酮的含量。在三分之二的样本中，有男性胎儿的怀孕。在怀孕12-18周期间，AF的睾丸激素超过了女性样本中发现的上限，重叠最小。尽管与男性和女性胎儿相关的AF睾酮水平在足月时都显著降低，但性别差异仍然存在。在妊娠9-19周期间，胎儿性别也被发现影响AF 170hp，一种被认为主要来自胎盘和胎儿肾上腺的类固醇；在这种情况下，女性的水平高于男性。意识到性别和妊娠对这些类固醇的房颤浓度的影响是将它们应用于内分泌疾病(如先天性肾上腺增生)产前诊断的重要前提。妊娠12~18周的房颤孕酮水平无性别差异。34-40周女性胎儿的孕酮浓度中位数较高，但这种差异可能与从男性和女性胎儿采集的房颤样本的胎龄不同有关。
Concentrations of unconjugated testosterone, 17-hydroxyprogesterone (170HP) and progesterone were measured by radioimmunoassay in amniotic fluid (AF) specimens from normal pregnancies of 9-40 weeks gestation. In two-thirds of samples from pregnancies with male fetuses. AF testosterone exceeded the upper limit found in female samples, with minimal overlap in the 12-18 week period of gestation. Although AF testosterone levels associated with male and female fetuses were both significantly lower toward term, the sex-difference persisted. Between 9-19 weeks gestation, fetal sex was also found to influence AF 170HP, a steroid thought to be predominantly of placental and fetal adrenal origin; in this case, female levels exceeded male. Awareness of the influence of sex and gestation upon AF concentrations of these steroids is an important prerequisite for their application to the prenatal diagnosis of endocrine disease (e.g., congenital adrenal hyperplasia). There was no sex difference in AF progesterone concentrations at 12-18 weeks gestation. The median progesterone concentration at 34-40 weeks was higher with female fetuses, but this difference may be related to a difference in gestational age between AF samples obtained from male and female fetuses.