The effects of a subpsychotic dose of ketamine on recognition and source memory for agency: implications for pharmacological modelling of core symptoms of schizophrenia.
The effects of a subpsychotic dose of ketamine on recognition and source memory for agency: implications for pharmacological modelling of core symptoms of schizophrenia.
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DOI：
10.1038/sj.npp.1300846
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发表时间：
2006-02
影响因子：
7.6
通讯作者：
Fletcher, PC
中科院分区：
文献类型：
--
作者：
Honey, GD;O'Loughlin, C;Turner, DC;Pomarol-Clotet, E;Corlett, PR;Fletcher, PC
氯胺酮越来越多地被用于模拟精神分裂症的认知缺陷和症状。我们调查了健康志愿者服用氯胺酮在多大程度上再现了精神分裂症中报道的情景识别记忆和代理源监测的缺陷。在一项双盲、安慰剂对照、随机、受试者内研究中，12名健康志愿者静脉输注安慰剂或100 ng/ml氯胺酮。为了回应所呈现的单词，受试者或实验者执行深度或浅层编码任务，提供2（药物）× 2（处理深度）× 2（代理）析因设计。在测试中，受试者区分新旧单词，并回忆来源（任务和代理）。使用多项模型分析数据，以确定项目识别，代理和任务的源记忆，以及猜测偏差。在氯胺酮的作用下，项目识别和对深度编码项目的线索回忆受到了损害，这与之前的研究结果相同。与精神分裂症相比，在氯胺酮的作用下，外化代理来源猜测偏差的倾向有所降低。虽然使用氯胺酮观察到的识别记忆缺陷与先前的工作和精神分裂症一致，但源记忆的变化与精神分裂症患者的报道不同。这种差异可能解释了氯胺酮引起的精神病理模式。
Ketamine is increasingly used to model the cognitive deficits and symptoms of schizophrenia. We investigated the extent to which ketamine administration in healthy volunteers reproduces the deficits in episodic recognition memory and agency source monitoring reported in schizophrenia. Intravenous infusions of placebo or 100 ng/ml ketamine were administered to 12 healthy volunteers in a double-blind, placebo-controlled, randomized, within-subjects study. In response to presented words, the subject or experimenter performed a deep or shallow encoding task, providing a 2(drug) × 2(depth of processing) × 2(agency) factorial design. At test, subjects discriminated old/new words, and recalled the sources (task and agent). Data were analyzed using multinomial modelling to identify item recognition, source memory for agency and task, and guessing biases. Under ketamine, item recognition and cued recall of deeply encoded items were impaired, replicating previous findings. In contrast to schizophrenia, there was a reduced tendency to externalize agency source guessing biases under ketamine. While the recognition memory deficit observed with ketamine is consistent with previous work and with schizophrenia, the changes in source memory differ from those reported in schizophrenic patients. This difference may account for the pattern of psychopathology induced by ketamine.
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影响因子：
7.6
作者：
Honey, RAE;Honey, GD;O'Loughlin, C;Sharar, SR;Kumaran, D;Bullmore, ET;Menon, DK;Donovan, T;Lupson, VC;Bisbrown-Chippendale, R;Fletcher, PC
通讯作者：
Fletcher, PC
影响因子：
5.4
作者：
BATCHELDER, WH;RIEFER, DM
通讯作者：
RIEFER, DM
影响因子：
3.1
作者：
BENTALL, RP;BAKER, GA;HAVERS, S
通讯作者：
HAVERS, S
影响因子：
4.5
作者：
Brebion, G;Smith, MJ;Amador, X
通讯作者：
Amador, X
DOI：
10.1016/s0022-5371(72)80001-x
发表时间：
1972-01-01
期刊：
JOURNAL OF VERBAL LEARNING AND VERBAL BEHAVIOR
影响因子：
--
作者：
CRAIK, FIM;LOCKHART, RS
通讯作者：
LOCKHART, RS