ACUTE AND CHRONIC EFFECTS OF COCAINE ON ISOLATION-INDUCED AGGRESSION IN MICE
ACUTE AND CHRONIC EFFECTS OF COCAINE ON ISOLATION-INDUCED AGGRESSION IN MICE
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DOI：
10.1007/bf02245741
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发表时间：
1990-01-01
影响因子：
3.4
通讯作者：
MARTIN, BR
中科院分区：
文献类型：
--
作者：
DARMANI, NA;HADFIELD, MG;MARTIN, BR
本研究的目的是研究急性和慢性可卡因给药对小鼠攻击行为的影响。通过单独圈养6周，使动物更具攻击性。分组饲养的嗅觉缺失同种，这是没有侵略性的入侵者控制。在急性研究中，可卡因在低剂量（0.5-5 mg/kg）下未引起攻击行为的显著变化，但在10和20 mg/kg剂量下显著降低了攻击行为。当每天两次以0.5或1 mg/kg的低剂量注射小鼠一周时，考马斯亮蓝增加了隔离诱导的小鼠攻击行为。特别是，药物显著降低了首次攻击的潜伏期，并且显著增加了对非攻击性入侵者的攻击频率。在所描述的治疗方案下，较高的可卡因剂量（10或20 mg/kg）降低了这些激动性库。对高剂量可卡因持续治疗的抗攻击作用没有产生耐受性。
The purpose of the present study was to investigate the effects of acute and chronic cocaine administration on aggressive behaviour in mice. The animals were made more aggressive by individual housing for a period of 6 weeks. Group-housed anosmic conspecifics which were not aggressive were used as intruder controls. In acute studies, cocaine induced no significant change in aggressive behaviour at low doses (0.5-5 mg/kg) but significantly decreased aggressive behaviour after doses of 10 and 20 mg/kg. Cocaine increased the isolation-induced aggressive behaviour in mice when they were injected twice daily for a week with low doses of 0.5 or 1 mg/kg. In particular, the latency to first attack was significantly decreased by the drug and the frequency of attack towards the non-aggressive intruder was dramatically increased. Higher cocaine doses (10 or 20 mg/kg) under the described treatment regimen decreased these agonistic repertories. Tolerance did not develop to the anti-aggressive effects of high doses of cocaine on continued treatment.