INFLUENCE OF HYPOTHERMIA AND CIRCULATORY ARREST ON CEREBRAL TEMPERATURE DISTRIBUTIONS
INFLUENCE OF HYPOTHERMIA AND CIRCULATORY ARREST ON CEREBRAL TEMPERATURE DISTRIBUTIONS
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DOI：
10.1115/1.3138569
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发表时间：
1985-01-01
影响因子：
1.7
通讯作者：
EBERHART, RC
中科院分区：
文献类型：
--
作者：
OLSEN, RW;HAYES, LJ;EBERHART, RC
建立了一个生物热传递方程的有限元模型，用于模拟亚人灵长类动物（猕猴）头部的温度分布。模拟深低温诱导和随后的低温停循环（HCA）。采用不同的表面传热系数和组织代谢产热值对停循环阶段进行了模拟。数值计算结果与实验数据进行了比较。模拟表明，大脑在冷动脉血注入后迅速冷却到接近等温的状态。然而，脑外结构冷却得慢得多。HCA期间大脑获得的大量热量是由于来自这些较温暖的脑外组织的热传递。这些结果表明，通过心肺转流（CPB）结合表面冷却垫的延长冷却应减少甚至防止HCA期间脑温度的升高。
A finite element model of the bioheat transfer equation has been developed to simulate the temperature distribution in the head of a subhuman primate [macaque]. Simulations were made of the induction of deep hypothermia and of subsequent hypothermic circulatory arrest (HCA). Simulations of the circulatory arrest phase were performed with different values of surface heat transfer coefficient and tissue metabolic heat generation. Numerical results were compared with experimental data for the same procedure. The simulations indicate the brain cools rapidly to a near isothermal condition in response to an infusion of cold arterial blood. However, extracerebral structures cool much more slowly. The bulk of heat gain by the brain during HCA is due to heat transfer from these warmer extra-cerebral tissues. These results suggest extended cooling by cardiopulmonary bypass (CPB) combined with surface cooling pads should reduce or even prevent the rise of brain temperatures during HCA.