D-aspartate in human brain.
D-aspartate in human brain.
复制标题
人脑中的 D-天冬氨酸。
DOI：
10.1111/j.1471-4159.1987.tb04122.x
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发表时间：
1987
影响因子：
4.7
通讯作者：
Frey2nd,WH
中科院分区：
文献类型：
--
作者：
Man,EH;Fisher,GH;Payan,IL;Cadilla-Perezrios,R;Garcia,NM;Chemburkar,R;Arends,G;Frey2nd,WH
此前已有报道称，人类大脑白质中存在生物学上罕见的 D-天冬氨酸（D-天冬氨酸）。早期的研究现已扩展到包括 67 个正常大脑的 D/L-天冬氨酸比率。数据显示，D-天冬氨酸含量从 1 岁到~35 岁迅速增加，在中年时趋于平稳，然后似乎有所下降。在整个人类生命周期中，灰质中的 D-天冬氨酸含量始终保持在较低水平（白质中的一半）。在当前分析方法的限制下，与正常受试者的大脑相比，患有阿尔茨海默病和其他几种疾病的大脑白质和灰质中的 D/L-天冬氨酸比率没有可检测到的差异。然而，在成人寿命期间，白质中存在显着的 D-天冬氨酸水平可能会导致与大脑老化相关功能障碍相关的蛋白质构型发生变化。
The presence of the biologically uncommon D‐aspartic acid (D‐aspartate) in hu manbrain white matter has been previously reported. The earlier study has now been expanded to include D/L‐aspartate ratios from 67 normal brains. The data show that the D‐aspartate content increases rapidly from 1 year to ∼35 years of age, levels off in middle age, and then appears to decrease somewhat. The D‐aspartate content in gray matter remains at a consistently low level (half of that found in white matter) throughout the human life span. Within the limitations of current analytical methods, there was no detectable difference in D/L‐aspartateratios in white and gray matter of brains with Alzheimer's disease and several other pathologies when compared with brains of normal subjects. However, the presence of a significant D‐aspartate level in white matter during the adult life span may lead to changes in protein configuration related to dysfunctions associated with the aging brain.