Change in cortical bone density and its distribution differs between boys and girls during puberty
Change in cortical bone density and its distribution differs between boys and girls during puberty
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DOI：
10.1210/jc.2006-0136
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发表时间：
2006-07-01
影响因子：
5.8
通讯作者：
Mckay, Heather A.
中科院分区：
文献类型：
--
作者：
Kontulainen, Saija A.;Macdonald, Heather M.;Mckay, Heather A.
理念：与青春期后男孩和男性相比，绝经后女孩和绝经前妇女的皮质骨密度（CoD，毫克/立方厘米）分别高出3-4%。女性致密的皮质骨被认为是生殖所需的钙库。然而，前瞻性的数据是缺乏描述的辅酶D的发展和骨矿物质密度分布在青春期在both sexual.Objective：因此，我们的目标是评估成熟和性别差异在20个月的变化的辅酶D和径向分布的骨矿物质密度（RDBMD，毫克每立方厘米）在早期，青春期，和青春期后的女孩和男孩。成熟组基于月经初潮状态（女孩，n = 68）和阴毛阶段（坦纳）（男孩，n = 59）的变化。结果：治疗后CoD平均增加1.9% [22.8 mg/cm（3）; 95%可信区间（CI）10 - 36]，2.8%[22.8 mg/cm（3）; 95%可信区间（CI）10-36]，2.8%[22.8 mg/cm（3）; 95%可信区间（CI）10-36]。与男孩相比，青春期早期、青春期中期和青春期后的女孩分别高出33.8 mg/cm（3）; 95% CI，21-47）和1.5%（55.0 mg/cm（3）; 95% CI，17-93）。RDBMD的分析显示，密度分布的变化不同的青春期组的女孩。在整个青春期，所有的女孩都表现出高密度皮质中部区域的增加，而只有青春期前后的女孩表现出较低密度皮质下区域的增加。在RDBMD变化的性别差异，注意到在早期和青春期前后groups.Conclusions：我们的研究结果的性别二型性的CoD发展的假设，女性骨存款钙的生殖需要巩固皮质骨在青春期。
Concept: Postmenarchal girls and premenopausal women have 3-4% higher cortical bone density (CoD, milligrams per cubic centimeter), compared with postpubertal boys and men, respectively. Females' denser cortical bone is thought to serve as a calcium reservoir for reproductive needs. However, prospective data are lacking that describe CoD development and bone mineral density distribution during puberty in both sexes.Objective: Thus, our objectives were to assess maturity and sex differences in the 20-month change of CoD and radial distribution of bone mineral density (RDBMD, milligrams per cubic centimeter) in early-, peri-, and postpubertal girls and boys. Maturity groups were based on change in menarcheal status (girls, n = 68) and pubic hair stage (Tanner) (boys, n = 59). Peripheral quantitative computed tomography was used to measure CoD and RDBMD at the tibial middiaphysis.Results: The increase in average CoD was 1.9% [22.8 mg/cm(3); 95% confidence interval (CI), 10-36], 2.8% (33.8 mg/cm(3); 95% CI, 21-47), and 1.5% (55.0 mg/cm(3); 95% CI, 17-93) greater in early, peri-, and postpubertal girls, compared with boys, respectively. Analysis of RDBMD revealed that the change in density distribution varied across pubertal groups in girls. Across puberty, all girls showed an increase in the high density midcortical region, whereas only peripubertal girls showed an increase in the lower density subcortical region. A sex-difference in RDBMD change was noted within early and peripubertal groups.Conclusions: Our findings of sexual dimorphism in CoD development give support to the hypothesis that female bone deposits calcium for reproductive needs by consolidation of cortical bone during puberty.