The Hippo-YAP/TAZ pathway mediates geranylgeranylation signaling in breast cancer progression
The Hippo-YAP/TAZ pathway mediates geranylgeranylation signaling in breast cancer progression
复制标题
Hippo-YAP/TAZ 通路介导乳腺癌进展中的香叶基香叶基化信号传导
DOI：
10.4161/23723548.2014.969638
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发表时间：
2016-01-01
影响因子：
2.1
通讯作者：
Yang, Wannian
中科院分区：
文献类型：
--
作者：
Lin, Qiong;Yang, Wannian
摘要蛋白质香叶基香叶基化（GGylation）调节包括小G蛋白酶和G γ亚基在内的多种信号转导子的功能。GGylation在乳腺癌进展中的作用知之甚少。最近的研究表明，GGylation通过Hippo-YAP/TAZ途径促进乳腺癌细胞的增殖和迁移。
ABSTRACT Protein geranylgeranylation (GGylation) regulates the function of various signal transducers including small GTPases and Ggamma subunits. The role of GGylation in breast cancer progression is poorly understood. Recent studies suggest that GGylation promotes the proliferation and migration of breast carcinoma cells through the Hippo-YAP/TAZ pathway.